{"entity":{"id":"finaldose","kind":"company","name":"FinalDose","aka":[],"tldr":"Y Combinator Spring 2026 start-up building a programmable DNA-targeting drug: a molecule that recognises a cancer-specific DNA sequence inside a cell and triggers a kill switch only there.","summary":"Founded by three Oxford PhDs (Jeff Liu, Li-Yao Huang, Steven Lin). The pitch: swap the guide sequence and the same drug becomes a new drug, unlocking 'undruggable' drivers such as MYC, TP53, and APC at the DNA level and, the company claims, 80% of cancers that protein-targeted drugs cannot reach. Preclinical and pre-revenue, with no published data or trials by September 2026. Listed here as the clearest example of the sequence-programmable therapeutic concept.","asOf":"2026-09-04","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/finaldose"},{"label":"Company site","url":"https://www.finaldose.ai/"}],"tags":["frontier","early-stage","yc"],"related":[],"cancers":[],"sections":["targeted-therapy","drug-discovery"],"technologies":["programmable-dna-targeting-therapeutics"],"targets":["tp53","kras"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"San Francisco, CA","country":"US","companyType":"biotech","website":"https://www.finaldose.ai/","founded":2026,"stage":"startup","ycBatch":"X26","investors":["y-combinator"],"funding":[]},"route":"/companies/finaldose/","neighbours":{"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"},{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"technology":[{"id":"programmable-dna-targeting-therapeutics","kind":"technology","name":"Programmable DNA-targeting therapeutics","route":"/technologies/programmable-dna-targeting-therapeutics/"}],"target":[{"id":"kras","kind":"target","name":"KRAS","route":"/targets/kras/"},{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"company":[{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}],"bottleneck":[{"id":"b-dose-optimisation","kind":"bottleneck","name":"Wrong doses","route":"/bottlenecks/b-dose-optimisation/"}]}}