{"entity":{"id":"fbxw11","kind":"target","name":"FBXW11","aka":["F-box and WD repeat domain containing 11","F-box/WD repeat-containing protein 11","KIAA0696","Fbw1b","BTRCP2","BTRC2","Hos","Fbw11","FBXW1B"],"tldr":"FBXW11 (F-box/WD repeat-containing protein 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13607"},{"label":"UniProt Q9UKB1","url":"https://www.uniprot.org/uniprotkb/Q9UKB1/entry"},{"label":"NCBI Gene 23291","url":"https://www.ncbi.nlm.nih.gov/gene/23291"},{"label":"Ensembl ENSG00000072803","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072803"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Salivary Gland Basal Cell Adenoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FBXW11","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:13607","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13607","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UKB1","url":"https://www.uniprot.org/uniprotkb/Q9UKB1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FBXW11","url":"https://civicdb.org/features/9443","note":"1 evidence items, 0 assertions, 1 variants; diseases: Salivary Gland Basal Cell Adenoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"not-established","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA FBXW11: RNA low tissue specificity; high antibody staining in 11 normal tissues. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas FBXW11 tissue","url":"https://www.proteinatlas.org/ENSG00000072803-FBXW11/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000072803 associations","url":"https://platform.opentargets.org/target/ENSG00000072803/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:13607","ensembl":"ENSG00000072803","uniprot":"Q9UKB1","entrez":"23291","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9734811/","biology":"Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Location: Cytoplasm; Nucleus (UniProt). Locus 5q35.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fbxw11/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}