{"entity":{"id":"fanci","kind":"target","name":"FANCI","aka":["FA complementation group I","Fanconi anemia group I protein","FLJ10719","KIAA1794"],"tldr":"FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.","summary":"Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.30, genetic association 0.50, genetic literature 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:25568","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25568"},{"label":"UniProt Q9NVI1","url":"https://www.uniprot.org/uniprotkb/Q9NVI1/entry"},{"label":"NCBI Gene 55215","url":"https://www.ncbi.nlm.nih.gov/gene/55215"},{"label":"Ensembl ENSG00000140525","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140525"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword \"DNA repair\". Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FANCI","role":["dna-repair"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:25568","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25568","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NVI1","url":"https://www.uniprot.org/uniprotkb/Q9NVI1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140525","url":"https://platform.opentargets.org/target/ENSG00000140525/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:25568","ensembl":"ENSG00000140525","uniprot":"Q9NVI1","entrez":"55215","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, \"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11347906/","biology":"Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/fanci/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}