{"entity":{"id":"etv4","kind":"target","name":"ETV4","aka":["ETS variant transcription factor 4","ETS translocation variant 4","E1A-F","E1AF","PEA3"],"tldr":"ETV4 (ETS translocation variant 4) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Lung cancer, Pancreatic ductal adenocarcinoma and 1 more.","summary":"Transcriptional activator. Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborisation of specific motor neuron axons within their target muscles. Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons.\n\nCIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Trametinib. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.23, somatic mutation 0.97). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Neuroblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3493"},{"label":"UniProt P43268","url":"https://www.uniprot.org/uniprotkb/P43268/entry"},{"label":"NCBI Gene 2118","url":"https://www.ncbi.nlm.nih.gov/gene/2118"},{"label":"Ensembl ENSG00000175832","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175832"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["prostate","lung-cancer","pancreatic","neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETV4","role":["drug-target","oncogene-driver","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3493","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P43268","url":"https://www.uniprot.org/uniprotkb/P43268/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETV4","url":"https://civicdb.org/features/1767","note":"3 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Prostate Cancer, Pancreatic Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000175832","url":"https://platform.opentargets.org/target/ENSG00000175832/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: prostate cancer 0.58 (GraphQL API, CC0)"},{"label":"IntOGen ETV4","url":"https://www.intogen.org/search?gene=ETV4","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA ETV4: RNA low tissue specificity; high antibody staining in 9 normal tissues; highest cancer staining colorectal cancer (5 of 12 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Lung cancer (all types), Pancreatic ductal adenocarcinoma, Childhood cancers (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P43268","url":"https://www.uniprot.org/uniprotkb/P43268/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETV4","url":"https://civicdb.org/features/1767","note":"3 evidence items, 0 assertions, 1 variants; diseases: Lung Cancer, Prostate Cancer, Pancreatic Cancer (GraphQL API, CC0)"},{"label":"IntOGen ETV4","url":"https://www.intogen.org/search?gene=ETV4","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas ETV4 tissue","url":"https://www.proteinatlas.org/ENSG00000175832-ETV4/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000175832 associations","url":"https://platform.opentargets.org/target/ENSG00000175832/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3493","ensembl":"ENSG00000175832","uniprot":"P43268","entrez":"2118","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Higashino et al, Nucleic Acids Res, 1993, \"Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8441666/","biology":"Transcriptional activator. Regulates the positioning of motor neurons within the lateral medial column of the spinal cord and controls the terminal arborisation of specific motor neuron axons within their target muscles. Required for the expression of CDH8 and SEMA3E in ETV4-expressing motor neurons and for the exclusion of CDH7 expression from these neurons. May play a role in keratinocyte differentiation. Location: Nucleus (UniProt). Locus 17q21.31 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.58 with prostate cancer (MONDO_0008315); CIViC evidence names this disease","Lung cancer: CIViC evidence names this disease","Pancreatic ductal adenocarcinoma: CIViC evidence names this disease","Neuroblastoma: IntOGen driver in 1 cohort (NBL)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/etv4/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}