{"entity":{"id":"ets2","kind":"target","name":"ETS2","aka":["ETS proto-oncogene 2, transcription factor"],"tldr":"ETS2 (ETS proto-oncogene 2, transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-small-cell lung cancer.","summary":"Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel and Cisplatin.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3489"},{"label":"UniProt P15036","url":"https://www.uniprot.org/uniprotkb/P15036/entry"},{"label":"NCBI Gene 2114","url":"https://www.ncbi.nlm.nih.gov/gene/2114"},{"label":"Ensembl ENSG00000157557","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157557"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETS2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3489","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3489","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15036","url":"https://www.uniprot.org/uniprotkb/P15036/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETS2","url":"https://civicdb.org/features/1763","note":"1 evidence items, 0 assertions, 1 variants; diseases: Lung Non-small Cell Carcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ETS2: RNA low tissue specificity; blood lineage group enriched (dendritic cells 34 nTPM, granulocytes 37 nTPM, monocytes 33 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas ETS2 tissue","url":"https://www.proteinatlas.org/ENSG00000157557-ETS2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000157557 associations","url":"https://platform.opentargets.org/target/ENSG00000157557/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3489","ensembl":"ENSG00000157557","uniprot":"P15036","entrez":"2114","firstDescribed":1985,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Watson D.K. et al, Proc. Natl. Acad. Sci. U.S.A, 1985, \"The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2997781/","biology":"Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. Location: Nucleus (UniProt). Locus 21q22.2 (HGNC).","whereFound":["Non-small-cell lung cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ets2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}