{"entity":{"id":"ets1","kind":"target","name":"ETS1","aka":["ETS proto-oncogene 1, transcription factor","FLJ10768","ETS-1","EWSR2"],"tldr":"ETS1 (ETS proto-oncogene 1, transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3488","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3488"},{"label":"UniProt P14921","url":"https://www.uniprot.org/uniprotkb/P14921/entry"},{"label":"NCBI Gene 2113","url":"https://www.ncbi.nlm.nih.gov/gene/2113"},{"label":"Ensembl ENSG00000134954","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134954"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ETS1","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3488","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3488","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P14921","url":"https://www.uniprot.org/uniprotkb/P14921/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ETS1","url":"https://civicdb.org/features/1762","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ETS1: RNA tissue enhanced (lymphoid tissue 253 nTPM); high antibody staining in 4 normal tissues; highest cancer staining lymphoma (5 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas ETS1 tissue","url":"https://www.proteinatlas.org/ENSG00000134954-ETS1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000134954 associations","url":"https://platform.opentargets.org/target/ENSG00000134954/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3488","ensembl":"ENSG00000134954","uniprot":"P14921","entrez":"2113","firstDescribed":1985,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Watson D.K. et al, Proc. Natl. Acad. Sci. U.S.A, 1985, \"The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2997781/","biology":"Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. Acts as a dominant-negative for isoform c-ETS-1A. Location: Nucleus; Cytoplasm (UniProt). Locus 11q24.3 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ets1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}