{"entity":{"id":"ethiodized-oil","kind":"drug","name":"Ethiodized oil","aka":["Ethiodol","Iodised poppy-seed oil"],"tldr":"Lipiodol is an iodine-rich oil injected into the liver's artery that lodges in liver tumours; it lets radiologists see them on CT and is the vehicle that carries chemotherapy into the tumour in conventional chemoembolisation for liver cancer.","summary":"Ethiodized oil has been approved in the United States since 1954, originally for lymphangiography and hysterosalpingography. In 2014 the FDA added selective hepatic intra-arterial use for imaging tumours in adults with known hepatocellular carcinoma, formalising its decades-old role in conventional transarterial chemoembolisation, where it is emulsified with doxorubicin or cisplatin and injected before the feeding vessels are blocked. The oil is also the carrier for iodine-131 lipiodol and for imaging hepatocellular carcinoma nodules on follow-up CT. Guerbet manufactures it.","status":"established","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Ethiodized_oil","links":[{"label":"Drugs@FDA NDA009190","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=009190"},{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Ethiodized_oil"}],"tags":["gap-fill","chembl-universe"],"related":[],"cancers":["hcc"],"sections":[],"technologies":["tace"],"targets":[],"drugs":["doxorubicin"],"companies":["guerbet"],"institutions":[],"pathways":[],"terms":[],"trials":["nct02762266","nct02971345","nct02755311"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"brand":"Lipiodol","modality":"Oily iodinated contrast agent for hepatic arterial injection","mechanism":"An iodinated poppy-seed oil that is retained selectively by hepatocellular carcinoma after hepatic arterial injection, both showing the tumour on CT and carrying chemotherapy into it during chemoembolisation.","approvals":[{"region":"US","year":1954,"indication":"Lymphangiography and hysterosalpingography; selective hepatic intra-arterial imaging of hepatocellular carcinoma added in 2014"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ethiodized-oil/","neighbours":{"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"technology":[{"id":"tace","kind":"technology","name":"Transarterial chemoembolisation (TACE)","route":"/technologies/tace/"}],"drug":[{"id":"doxorubicin","kind":"drug","name":"Doxorubicin","route":"/drugs/doxorubicin/"}],"company":[{"id":"guerbet","kind":"company","name":"Guerbet","route":"/companies/guerbet/"}],"trial":[{"id":"nct02971345","kind":"trial","name":"Endovascular Brachytherapy Combined With Stent Placement and TACE for HCC With Main Portal Vein Tumor Thrombus","route":"/trials/nct02971345/"},{"id":"nct02755311","kind":"trial","name":"Liver Resection Versus Transarterial Chemoembolization for the Treatment of Intermediate-stage Hepatocellular Carcinoma","route":"/trials/nct02755311/"},{"id":"nct05672108","kind":"trial","name":"Phase II Trial of Lung Chemoemobolization","route":"/trials/nct05672108/"},{"id":"nct02762266","kind":"trial","name":"Transarterial Chemoembolization Compared With Stereotactic Body Radiation Therapy or Stereotactic Ablative Radiation Therapy in Treating Patients With Residual or Recurrent Liver Cancer Undergone Initial Transarterial Chemoembolization","route":"/trials/nct02762266/"}]}}