{"entity":{"id":"eric-fearon","kind":"person","name":"Eric R. Fearon","aka":[],"tldr":"Co-author of the Fearon-Vogelstein model of how colorectal cancer develops step by step.","summary":"Eric R. Fearon is Director of the Rogel Cancer Center and Emanuel N. Maisel Professor of Oncology at the University of Michigan. He is a molecular geneticist known as co-author of the Fearon-Vogelstein model describing how colorectal cancer develops step by step, and for cloning the DCC gene. His selected paper sets out a genetic model for colorectal tumorigenesis. He now directs the Rogel Cancer Center while continuing to study Wnt and APC signalling and tumour suppressor genes in colorectal cancer.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Eric_Fearon","links":[{"label":"Rogel Cancer Center","url":"https://www.rogelcancercenter.org"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Fearon%20ER%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["michigan-rogel"],"pathways":["wnt"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Rogel Cancer Center; Emanuel N. Maisel Professor of Oncology","institutionId":"michigan-rogel","specialisms":["Colorectal cancer genetics","Wnt/APC signalling","Tumour suppressor genes"],"profiles":[{"label":"Rogel Cancer Center","url":"https://www.rogelcancercenter.org"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Fearon%20ER%5BAuthor%5D"}],"papers":[{"title":"A genetic model for colorectal tumorigenesis","journal":"Cell","year":1990,"url":"https://doi.org/10.1016/0092-8674(90)90186-I","doi":"10.1016/0092-8674(90)90186-I"}],"orcid":"0000-0003-2867-3971"},"route":"/people/eric-fearon/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"institution":[{"id":"michigan-rogel","kind":"institution","name":"University of Michigan Rogel Cancer Center","route":"/institutions/michigan-rogel/"}],"pathway":[{"id":"wnt","kind":"pathway","name":"Wnt / β-catenin","route":"/pathways/wnt/"}],"paper":[{"id":"paper-fearon-cell","kind":"paper","name":"A genetic model for colorectal tumorigenesis","route":"/key-papers/paper-fearon-cell/"},{"id":"paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988","kind":"paper","name":"Genetic alterations during colorectal-tumor development","route":"/key-papers/paper-vogelstein-genetic-alterations-colorectal-tumor-development-nejm-1988/"}]}}