{"entity":{"id":"ephb1","kind":"target","name":"EPHB1","aka":["EPH receptor B1","Ephrin type-B receptor 1","Hek6","EPHT2"],"tldr":"EPHB1 (Ephrin type-B receptor 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Thyroid cancer and Neuroendocrine tumours.","summary":"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.93, animal model 0.47, genetic association 0.35, clinical 0.93).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3392","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3392"},{"label":"UniProt P54762","url":"https://www.uniprot.org/uniprotkb/P54762/entry"},{"label":"NCBI Gene 2047","url":"https://www.ncbi.nlm.nih.gov/gene/2047"},{"label":"Ensembl ENSG00000154928","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154928"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["thyroid","neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.93. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EPHB1","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3392","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3392","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P54762","url":"https://www.uniprot.org/uniprotkb/P54762/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000154928","url":"https://platform.opentargets.org/target/ENSG00000154928/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: thyroid cancer 0.56, neuroendocrine neoplasm 0.54 (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA EPHB1: RNA tissue enhanced (brain 19 nTPM); blood lineage group enriched (dendritic cells 23 nTPM, granulocytes 10 nTPM); high antibody staining in 1 normal tissue. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Thyroid cancer, Neuroendocrine tumours); Open Targets associates it with 1 specific cancer type at or above 0.5 (medullary thyroid gland carcinoma). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas EPHB1 tissue","url":"https://www.proteinatlas.org/ENSG00000154928-EPHB1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000154928 associations","url":"https://platform.opentargets.org/target/ENSG00000154928/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3392","ensembl":"ENSG00000154928","uniprot":"P54762","entrez":"2047","firstDescribed":1995,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Tang X.X. et al, Genomics, 1995, \"cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8666391/","biology":"Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighboring cells. The signalling pathway downstream of the receptor is referred to as forward signalling while the signalling pathway downstream of the ephrin ligand is referred to as reverse signalling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Location: Cell membrane; Early endosome membrane; Cell projection, dendrite (UniProt). Locus 3q22.2 (HGNC).","whereFound":["Thyroid cancer: Open Targets association 0.56 with thyroid cancer (MONDO_0002108)","Neuroendocrine tumours: Open Targets association 0.54 with neuroendocrine neoplasm (MONDO_0019496)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/ephb1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}