{"entity":{"id":"epcore-dlbcl-2","kind":"trial","name":"EPCORE DLBCL-2","aka":[],"tldr":"Tests whether adding a bispecific to first-line chemotherapy cures more patients up front.","summary":"EPCORE DLBCL-2, trial NCT05578976 sponsored by Genmab and AbbVie, tests whether adding a fixed duration of the bispecific epcoritamab to first-line R-CHOP cures more patients with untreated diffuse large B-cell lymphoma up front. Topline results were announced in 2026 and presented at EHA 2026, and together with frontMIND and POLARIX the trial defines the frontline options for higher-risk disease. OnCo links it to lymphoma and epcoritamab. Whether a T-cell engager added to chemotherapy improves cure rates enough to justify its toxicity and cost in the first line is the question its data will answer.","status":"active","asOf":"2026-09-07","links":[{"label":"ClinicalTrials.gov NCT05578976","url":"https://clinicaltrials.gov/study/NCT05578976"}],"tags":[],"related":[],"cancers":["dlbcl"],"sections":[],"technologies":["t-cell-engager"],"targets":[],"drugs":["epcoritamab"],"companies":["genmab"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT05578976","phase":"3","setting":"Untreated DLBCL: epcoritamab + R-CHOP vs R-CHOP","sponsor":"Genmab / AbbVie","started":"2023-02-08","startedType":"actual","enrolledBasis":"registry","outcomes":[]},"route":"/trials/epcore-dlbcl-2/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"technology":[{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"drug":[{"id":"epcoritamab","kind":"drug","name":"Epcoritamab","route":"/drugs/epcoritamab/"}],"company":[{"id":"genmab","kind":"company","name":"Genmab","route":"/companies/genmab/"}],"idea":[{"id":"idea-ctdna-guided-dlbcl-frontline","kind":"idea","name":"ctDNA-guided escalation and de-escalation in frontline DLBCL","route":"/ideas/idea-ctdna-guided-dlbcl-frontline/"}]}}