{"entity":{"id":"energy-balance","kind":"term","name":"Energy balance","aka":["Energy balance and cancer","Physical activity, diet and adiposity"],"tldr":"The umbrella term researchers use for the combined effect of what you eat, how much you move and how much fat you carry. It is the framework linking diet, exercise and obesity research to cancer.","summary":"Energy balance research treats diet, physical activity and adiposity as one system acting through shared pathways (insulin, IGF-1, sex steroids, adipokines, inflammation, immune function). It underlies the design of trials such as CHALLENGE and BWEL and the NCI's Transdisciplinary Research on Energetics and Cancer programme. Its practical implication is that interventions on any one arm are confounded by, and may need to be combined with, the others.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Energy_homeostasis","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Energy_homeostasis"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["structured-exercise-survivorship","dietitian-led-weight-loss-breast","time-restricted-eating","mediterranean-plant-forward-diet"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["met-hours","obesity-related-cancers","metabolic-syndrome","glycaemic-index"],"trials":["challenge","bwel"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Nutrition & lifestyle"},"route":"/terms/energy-balance/","neighbours":{"technology":[{"id":"dietitian-led-weight-loss-breast","kind":"technology","name":"Dietitian-led weight-loss programmes in HR-positive breast cancer","route":"/technologies/dietitian-led-weight-loss-breast/"},{"id":"fasting-mimicking-diet","kind":"technology","name":"Fasting and fasting-mimicking diets around chemotherapy","route":"/technologies/fasting-mimicking-diet/"},{"id":"glp1-agonists-cancer-risk","kind":"technology","name":"GLP-1 receptor agonists and obesity-related cancer risk","route":"/technologies/glp1-agonists-cancer-risk/"},{"id":"mediterranean-plant-forward-diet","kind":"technology","name":"Mediterranean and plant-forward dietary patterns","route":"/technologies/mediterranean-plant-forward-diet/"},{"id":"structured-exercise-survivorship","kind":"technology","name":"Structured exercise programmes after curative treatment","route":"/technologies/structured-exercise-survivorship/"},{"id":"time-restricted-eating","kind":"technology","name":"Time-restricted eating in cancer prevention and survivorship","route":"/technologies/time-restricted-eating/"}],"term":[{"id":"dietary-pattern-scores","kind":"term","name":"Dietary pattern scores (Mediterranean, HEI, AHEI, DASH, WCRF/AICR)","route":"/terms/dietary-pattern-scores/"},{"id":"glycaemic-index","kind":"term","name":"Glycaemic index and glycaemic load","route":"/terms/glycaemic-index/"},{"id":"met-hours","kind":"term","name":"MET-hours per week","route":"/terms/met-hours/"},{"id":"metabolic-syndrome","kind":"term","name":"Metabolic syndrome and insulin resistance","route":"/terms/metabolic-syndrome/"},{"id":"obesity-related-cancers","kind":"term","name":"Obesity-related cancers (IARC list of 13)","route":"/terms/obesity-related-cancers/"}],"trial":[{"id":"bwel","kind":"trial","name":"BWEL (Breast Cancer Weight Loss, Alliance A011401)","route":"/trials/bwel/"},{"id":"challenge","kind":"trial","name":"CHALLENGE (CCTG CO.21)","route":"/trials/challenge/"},{"id":"whel","kind":"trial","name":"WHEL (Women's Healthy Eating and Living)","route":"/trials/whel/"}],"idea":[{"id":"idea-nl-exercise-dose-finding","kind":"idea","name":"A dose-finding trial for exercise after cancer","route":"/ideas/idea-nl-exercise-dose-finding/"},{"id":"idea-nl-glp1-adjuvant-hr-breast","kind":"idea","name":"GLP-1 receptor agonists as adjuvant weight-loss therapy in HR-positive breast cancer","route":"/ideas/idea-nl-glp1-adjuvant-hr-breast/"}],"pathway":[{"id":"lipid-metabolism-cancer","kind":"pathway","name":"Lipid synthesis, uptake & cholesterol","route":"/pathways/lipid-metabolism-cancer/"}]}}