{"entity":{"id":"endo","kind":"company","name":"Endo (now Keenova Therapeutics and Par Health)","aka":["Endo International plc","Endo Pharmaceuticals","Endo USA Inc., a Keenova Therapeutics Company","Endo USA Inc.","Keenova Therapeutics","Par Pharmaceutical, Inc.","Par Pharmaceutical","Par Health"],"tldr":"Endo was a specialty and generics pharmaceutical company, one of the busiest industry sponsors of phase 3 cancer trials on ClinicalTrials.gov; after merging with Mallinckrodt it became Keenova Therapeutics, with its generics arm spun off as Par Health.","summary":"Endo International plc, an Irish-registered pharmaceutical company formed from Endo Pharmaceuticals in 1997, marketed specialty medicines and, through Par Pharmaceutical, generics and sterile injectables, including cancer supportive-care and chemotherapy products. Its own site records that Mallinckrodt and Endo merged, that the combined company spun off the generics and sterile injectables business as Par Health, and that the specialty company was renamed Keenova Therapeutics in November 2025. ClinicalTrials.gov lists Endo USA and Par Pharmaceutical as lead sponsors of phase 3 cancer trials. Endo Pharmaceuticals relaunched Valstar (valrubicin), the intravesical anthracycline for BCG-refractory bladder carcinoma in situ, in 2009, and its registered phase 3 cancer trials include valrubicin maintenance in non-muscle-invasive bladder cancer (NCT01310803, NCT01316874) and the Vantas histrelin implant against goserelin in prostate cancer (NCT01394263); Par ran phase 3 trials of megestrol acetate suspension for cancer-related anorexia and cachexia (NCT00637728, NCT00637806).","asOf":"2026-09-11","wikipedia":"https://en.wikipedia.org/wiki/Endo_International","links":[{"label":"Official website","url":"https://www.endo.com"},{"label":"ClinicalTrials.gov: trials led by Endo International plc","url":"https://clinicaltrials.gov/search?lead=Endo%20International%20plc"},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q5376211"},{"label":"Wikipedia: valrubicin (Valstar)","url":"https://en.wikipedia.org/wiki/Valrubicin"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["urothelial","prostate"],"sections":[],"technologies":["bcg-and-intravesical-therapy"],"targets":[],"drugs":["valrubicin","histrelin","megestrol"],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Ireland","country":"IE","companyType":"pharma","website":"https://www.endo.com","founded":1997,"stage":"public","investors":[],"funding":[]},"route":"/companies/endo/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"bcg-and-intravesical-therapy","kind":"technology","name":"Intravesical therapy (BCG, chemotherapy, devices, gene and viral therapy)","route":"/technologies/bcg-and-intravesical-therapy/"}],"drug":[{"id":"histrelin","kind":"drug","name":"Histrelin","route":"/drugs/histrelin/"},{"id":"megestrol","kind":"drug","name":"Megestrol acetate","route":"/drugs/megestrol/"},{"id":"valrubicin","kind":"drug","name":"Valrubicin","route":"/drugs/valrubicin/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}],"trial":[{"id":"nct01310803","kind":"trial","name":"Multi-center Study to Evaluate the Efficacy and Safety of Maintenance Therapy With Valrubicin Versus no Maintenance, in Subjects Treated With Valrubicin Induction for Carcinoma in Situ (CIS) of the Bladder","route":"/trials/nct01310803/"},{"id":"nct01394263","kind":"trial","name":"Study of Histrelin Subdermal Implant in Patients With Prostate Cancer","route":"/trials/nct01394263/"},{"id":"nct01697384","kind":"trial","name":"Study to Evaluate Efficacy and Safety of Histrelin Subdermal Implant in Men With Advanced Prostate Cancer","route":"/trials/nct01697384/"}]}}