{"entity":{"id":"elizabeth-jaffee","kind":"person","name":"Elizabeth M. Jaffee","aka":[],"tldr":"Pancreatic cancer immunologist who developed the GVAX vaccine and led national cancer policy panels.","summary":"Elizabeth M. Jaffee is Deputy Director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Co-Director of the Skip Viragh Center for Pancreas Cancer. She is a pancreatic cancer immunologist known for developing the GVAX pancreas vaccine and for studies of how to convert immunologically cold pancreatic tumours into ones the immune system can see. Her selected paper shows that immunotherapy converts non-immunogenic pancreatic tumours into immunogenic foci of immune regulation. A former AACR president and chair of the NCI's National Cancer Advisory Board, she continues to work on cancer vaccines and checkpoint inhibitors in pancreatic cancer.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Elizabeth_Jaffee","links":[{"label":"Hopkins profile","url":"https://www.hopkinsmedicine.org/profiles/details/elizabeth-jaffee"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Jaffee%20EM%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["shared-antigen-vaccine","checkpoint-inhibitor"],"targets":[],"drugs":[],"companies":[],"institutions":["johns-hopkins"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-immunology-research"],"dependsOn":[],"notes":[],"role":"Deputy Director, Sidney Kimmel Comprehensive Cancer Center; Co-Director, Skip Viragh Center for Pancreas Cancer","institutionId":"johns-hopkins","specialisms":["Pancreatic cancer","Cancer vaccines","Tumour immunology"],"profiles":[{"label":"Hopkins profile","url":"https://www.hopkinsmedicine.org/profiles/details/elizabeth-jaffee"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Jaffee%20EM%5BAuthor%5D"}],"papers":[{"title":"Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation","journal":"Cancer Immunology Research","year":2014,"url":"https://doi.org/10.1158/2326-6066.CIR-14-0027","doi":"10.1158/2326-6066.CIR-14-0027"}]},"route":"/people/elizabeth-jaffee/","neighbours":{"cancer":[{"id":"msi-high-pdac","kind":"cancer","name":"Mismatch repair deficient (MSI-high) pancreatic ductal adenocarcinoma","route":"/cancers/msi-high-pdac/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"institution":[{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","route":"/institutions/johns-hopkins/"}],"journal":[{"id":"cancer-immunology-research","kind":"journal","name":"Cancer Immunology Research","route":"/journals/cancer-immunology-research/"}],"paper":[{"id":"paper-jones-pancreatic-core-pathways-science-2008","kind":"paper","name":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","route":"/key-papers/paper-jones-pancreatic-core-pathways-science-2008/"},{"id":"paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019","kind":"paper","name":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","route":"/key-papers/paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019/"},{"id":"paper-ho-pancreatic-tumour-microenvironment-review-nrco-2020","kind":"paper","name":"The tumour microenvironment in pancreatic cancer: clinical challenges and opportunities","route":"/key-papers/paper-ho-pancreatic-tumour-microenvironment-review-nrco-2020/"}]}}