{"entity":{"id":"eik1005","kind":"drug","name":"EIK1005","aka":[],"tldr":"EIK1005 is a small-molecule inhibitor from Eikon Therapeutics, in registered phase 2 trials for colorectal cancer, endometrial cancer.","summary":"EIK1005 is listed on ClinicalTrials.gov as an intervention in 1 registered phase 2 trial sponsored by Eikon Therapeutics, in colorectal cancer, endometrial cancer. Described in the registry record as a eik1005 is a selective inhibitor; the trial entries below carry the sponsor's wording. OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.","status":"phase-2","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of EIK1005","url":"https://clinicaltrials.gov/search?intr=EIK1005"},{"label":"ClinicalTrials.gov NCT07262619","url":"https://clinicaltrials.gov/study/NCT07262619"}],"tags":["pipeline","ctgov-ingest","registry-only"],"related":[],"cancers":["colorectal","endometrial"],"sections":[],"technologies":[],"targets":["wrn"],"drugs":[],"companies":["eikon-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07262619"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["EIK1005 is described in its registry record as a selective inhibitor of the Werner helicase, the synthetic-lethal dependency of microsatellite-unstable tumours, and is being tested alone and with pembrolizumab."],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2, registry-only)","editedOn":"2026-09-16"},"code":"EIK1005","modality":"Small-molecule inhibitor","mechanism":"Described in the registry record as a eik1005 is a selective inhibitor; the trial entries below carry the sponsor's wording.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/eik1005/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"msi-high-colorectal","kind":"cancer","name":"Mismatch-repair deficient (MSI-high) colorectal cancer","route":"/cancers/msi-high-colorectal/"}],"target":[{"id":"wrn","kind":"target","name":"WRN helicase (MSI-high cancers)","route":"/targets/wrn/"}],"company":[{"id":"eikon-therapeutics","kind":"company","name":"Eikon Therapeutics","route":"/companies/eikon-therapeutics/"}],"trial":[{"id":"nct07262619","kind":"trial","name":"EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Partic","route":"/trials/nct07262619/"}]}}