{"entity":{"id":"ednra","kind":"target","name":"EDNRA","aka":["endothelin receptor type A","Endothelin-1 receptor","ET-A","ETA-R","hET-AR"],"tldr":"EDNRA (Endothelin-1 receptor) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer.","summary":"Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, animal model 0.71, genetic association 0.00, clinical 0.85).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3179","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3179"},{"label":"UniProt P25101","url":"https://www.uniprot.org/uniprotkb/P25101/entry"},{"label":"NCBI Gene 1909","url":"https://www.ncbi.nlm.nih.gov/gene/1909"},{"label":"Ensembl ENSG00000151617","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000151617"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.85. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"EDNRA","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:3179","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3179","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P25101","url":"https://www.uniprot.org/uniprotkb/P25101/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000151617","url":"https://platform.opentargets.org/target/ENSG00000151617/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA EDNRA: RNA tissue enhanced (seminal vesicle 107 nTPM); no normal tissue stained high; highest cancer staining pancreatic cancer (2 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (prostate cancer). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas EDNRA tissue","url":"https://www.proteinatlas.org/ENSG00000151617-EDNRA/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000151617 associations","url":"https://platform.opentargets.org/target/ENSG00000151617/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3179","ensembl":"ENSG00000151617","uniprot":"P25101","entrez":"1909","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Adachi et al, Biochem. Biophys. Res. Commun, 1991, \"Cloning and characterization of cDNA encoding human A-type endothelin receptor\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1719979/","biology":"Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Location: Cell membrane (UniProt). Locus 4q31.22-q31.23 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/ednra/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"atrasentan","kind":"drug","name":"Atrasentan","route":"/drugs/atrasentan/"},{"id":"zibotentan","kind":"drug","name":"Zibotentan","route":"/drugs/zibotentan/"}],"trial":[{"id":"enthuse-m1-zibotentan","kind":"trial","name":"ENTHUSE M1","route":"/trials/enthuse-m1-zibotentan/"},{"id":"swog-s0421-atrasentan","kind":"trial","name":"SWOG S0421","route":"/trials/swog-s0421-atrasentan/"}]}}