{"entity":{"id":"ecscr","kind":"target","name":"ECSCR","aka":["endothelial cell surface expressed chemotaxis and apoptosis regulator","Endothelial cell-specific chemotaxis regulator","ECSM2"],"tldr":"ECSCR (Endothelial cell-specific chemotaxis regulator) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Angiogenesis Inhibitor.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:35454","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:35454"},{"label":"UniProt Q19T08","url":"https://www.uniprot.org/uniprotkb/Q19T08/entry"},{"label":"NCBI Gene 641700","url":"https://www.ncbi.nlm.nih.gov/gene/641700"},{"label":"Ensembl ENSG00000249751","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000249751"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ECSCR","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:35454","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:35454","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q19T08","url":"https://www.uniprot.org/uniprotkb/Q19T08/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ECSCR","url":"https://civicdb.org/features/26599","note":"1 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"not-established","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ECSCR: RNA low tissue specificity; no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas ECSCR tissue","url":"https://www.proteinatlas.org/ENSG00000249751-ECSCR/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000249751 associations","url":"https://platform.opentargets.org/target/ENSG00000249751/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:35454","ensembl":"ENSG00000249751","uniprot":"Q19T08","entrez":"641700","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, \"Complete sequencing and characterization of 21,243 full-length human cDNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14702039/","biology":"Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Location: Cell membrane; Cytoplasm (UniProt). Locus 5q31.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ecscr/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}]}}