{"entity":{"id":"dusp2","kind":"target","name":"DUSP2","aka":["dual specificity phosphatase 2","Dual specificity protein phosphatase 2","PAC-1"],"tldr":"DUSP2 (Dual specificity protein phosphatase 2) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3068"},{"label":"UniProt Q05923","url":"https://www.uniprot.org/uniprotkb/Q05923/entry"},{"label":"NCBI Gene 1844","url":"https://www.ncbi.nlm.nih.gov/gene/1844"},{"label":"Ensembl ENSG00000158050","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158050"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DUSP2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3068","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3068","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q05923","url":"https://www.uniprot.org/uniprotkb/Q05923/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DUSP2","url":"https://civicdb.org/features/1563","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA DUSP2: RNA tissue enhanced (bone marrow 122 nTPM); blood lineage group enriched (NK-cells 148 nTPM, T-cells 200 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas DUSP2 tissue","url":"https://www.proteinatlas.org/ENSG00000158050-DUSP2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000158050 associations","url":"https://platform.opentargets.org/target/ENSG00000158050/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3068","ensembl":"ENSG00000158050","uniprot":"Q05923","entrez":"1844","firstDescribed":1993,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Rohan et al, Science, 1993, \"PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/7681221/","biology":"Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1. Location: Nucleus (UniProt). Locus 2q11.2 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/dusp2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}