{"entity":{"id":"duration-of-response","kind":"term","name":"Duration of response","aka":["DoR","durable response","durable responses","durability","long-lasting responses","median duration of response"],"tldr":"How long a tumour stays shrunk once it has responded to a drug. A response that lasts two years is worth far more than one that lasts two months, so this is reported alongside response rate.","summary":"Measured from the first documented response to progression or death, and usually reported as a median plus the proportion of responders still responding at 6, 12 or 24 months. Immunotherapy's signature is not a high response rate but a long duration of response, with responses lasting years in a subset; conversely, many chemotherapy responses are brisk but short. Regulators weigh response rate and durability together when granting accelerated approval on single-arm data, and the durable-response tail is what turns survival curves into a plateau.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Response_evaluation_criteria_in_solid_tumors","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Response_evaluation_criteria_in_solid_tumors"}],"tags":[],"related":["partial-response","complete-response","orr","pfs","accelerated-approval","immunotherapy-term"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinic basics"},"route":"/terms/duration-of-response/","neighbours":{"term":[{"id":"accelerated-approval","kind":"term","name":"Accelerated approval","route":"/terms/accelerated-approval/"},{"id":"complete-response","kind":"term","name":"Complete response","route":"/terms/complete-response/"},{"id":"immunotherapy-term","kind":"term","name":"Immunotherapy","route":"/terms/immunotherapy-term/"},{"id":"orr","kind":"term","name":"Objective response rate (ORR)","route":"/terms/orr/"},{"id":"partial-response","kind":"term","name":"Partial response","route":"/terms/partial-response/"},{"id":"pfs","kind":"term","name":"Progression-free survival (PFS)","route":"/terms/pfs/"}]}}