{"entity":{"id":"douglas-lowy","kind":"person","name":"Douglas R. Lowy","aka":[],"tldr":"Co-developed the HPV vaccine technology that is eliminating cervical cancer in vaccinated populations.","summary":"Douglas R. Lowy is Principal Deputy Director of the National Cancer Institute, where he has also served as acting director. He is known for co-developing with John Schiller the virus-like particle technology underlying all licensed HPV vaccines, work recognised with the Lasker Award in 2017. His selected paper shows that the papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. His work on HPV biology and vaccine development is the basis for the prevention of cervical cancer and HPV-related head and neck cancer in vaccinated populations.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Douglas_R._Lowy","links":[{"label":"NCI leadership","url":"https://www.cancer.gov/about-nci/leadership"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lowy%20DR%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["cervical","head-and-neck"],"sections":[],"technologies":["hpv-vaccine"],"targets":[],"drugs":["gardasil-9"],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Principal Deputy Director, National Cancer Institute","institutionId":"nci","specialisms":["HPV biology","Vaccine development","Cancer prevention"],"profiles":[{"label":"NCI leadership","url":"https://www.cancer.gov/about-nci/leadership"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lowy%20DR%5BAuthor%5D"}],"papers":[{"title":"Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic","journal":"PNAS","year":1992,"url":"https://doi.org/10.1073/pnas.89.24.12180","doi":"10.1073/pnas.89.24.12180"}]},"route":"/people/douglas-lowy/","neighbours":{"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"technology":[{"id":"hpv-vaccine","kind":"technology","name":"HPV & HBV vaccination","route":"/technologies/hpv-vaccine/"}],"drug":[{"id":"gardasil-9","kind":"drug","name":"Nonavalent HPV vaccine","route":"/drugs/gardasil-9/"}],"institution":[{"id":"cancer-grand-challenges","kind":"institution","name":"Cancer Grand Challenges","route":"/institutions/cancer-grand-challenges/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}],"person":[{"id":"ian-frazer","kind":"person","name":"Ian Frazer","route":"/people/ian-frazer/"}]}}