{"entity":{"id":"douglas-levine","kind":"person","name":"Douglas A. Levine","aka":[],"tldr":"Surgeon-scientist who led the TCGA endometrial cancer study that created today's four molecular subtypes.","summary":"Douglas Levine led the TCGA integrated genomic characterisation of endometrial carcinoma, which defined the POLE ultramutated, microsatellite-unstable, copy-number-low and copy-number-high (p53-abnormal) subtypes now embedded in international guidelines and trials. He also co-led the TCGA ovarian cancer analysis and directs gynaecologic oncology at NYU Langone, where his laboratory studies the origins of high-grade serous cancer.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Levine%20DA%5BAuthor%5D%20endometrial%20genomic"}],"tags":["endometrial","genomics","surgery"],"related":[],"cancers":["endometrial","ovarian"],"sections":[],"technologies":["wes-wgs"],"targets":[],"drugs":[],"companies":[],"institutions":["nyu-perlmutter"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-tcga-pancancer-atlas-cell-2018"],"journals":[],"dependsOn":[],"notes":[],"role":"Director of Gynecologic Oncology, NYU Langone Perlmutter Cancer Center","institutionId":"nyu-perlmutter","specialisms":["Gynaecologic oncology surgery","Endometrial cancer genomics","Ovarian cancer genomics","Translational research"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Levine%20DA%5BAuthor%5D%20endometrial%20genomic"}],"papers":[{"title":"Integrated genomic characterization of endometrial carcinoma","journal":"Nature","year":2013,"doi":"10.1038/nature12113"},{"title":"Integrated genomic analyses of ovarian carcinoma","journal":"Nature","year":2011,"doi":"10.1038/nature10166"},{"title":"TCGA Pan-Cancer Atlas: 10,000 tumours across 33 cancer types, classified by molecular features","journal":"Cell","year":2018,"url":"https://doi.org/10.1016/j.cell.2018.03.022","doi":"10.1016/j.cell.2018.03.022"}],"orcid":"0000-0003-1038-8232"},"route":"/people/douglas-levine/","neighbours":{"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"technology":[{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"institution":[{"id":"nyu-perlmutter","kind":"institution","name":"Laura and Isaac Perlmutter Cancer Center at NYU Langone Health","route":"/institutions/nyu-perlmutter/"}],"paper":[{"id":"paper-tcga-pancancer-atlas-cell-2018","kind":"paper","name":"TCGA Pan-Cancer Atlas: 10,000 tumours across 33 cancer types, classified by molecular features","route":"/key-papers/paper-tcga-pancancer-atlas-cell-2018/"}]}}