{"entity":{"id":"doublet-triplet","kind":"term","name":"Doublet, triplet and quadruplet regimens","aka":["doublet","doublets","triplet","triplets","quadruplet","quadruplets","quad","two-drug","three-drug","four-drug","IO-TKI doublet","IO-IO","IO/IO","chemo-doublet","dual blockade","IO-TKI doublets"],"tldr":"Shorthand for how many active drugs are combined: a doublet is two, a triplet three, a quadruplet four. More drugs usually mean more responses and more side effects, and trials test whether the extra drug earns its place.","summary":"Platinum doublets (cisplatin or carboplatin plus a partner) are the chemotherapy standard in lung, bladder and ovarian cancer. FOLFOXIRI is a chemotherapy triplet; quadruplet induction (daratumumab, bortezomib, lenalidomide, dexamethasone) is now standard in myeloma; IO-TKI doublets (pembrolizumab-axitinib) and IO-IO doublets (nivolumab-ipilimumab) compete in kidney cancer; prostate cancer moved from ADT alone to doublets and triplets (ADT + ARPI + docetaxel, PEACE-1, ARASENS). The question in each case is whether the combination beats sequential use of the same drugs, which is rarely tested directly.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Combination_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Combination_therapy"}],"tags":[],"related":["chemotherapy-regimen","platinum-sensitivity","backbone-add-on","vrd"],"cancers":[],"sections":["chemotherapy"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/doublet-triplet/","neighbours":{"term":[{"id":"backbone-add-on","kind":"term","name":"Backbone, add-on and monotherapy","route":"/terms/backbone-add-on/"},{"id":"platinum-sensitivity","kind":"term","name":"Platinum-sensitive / platinum-resistant","route":"/terms/platinum-sensitivity/"},{"id":"chemotherapy-regimen","kind":"term","name":"Regimen and cycles","route":"/terms/chemotherapy-regimen/"},{"id":"taxane","kind":"term","name":"Taxanes (paclitaxel, docetaxel, nab-paclitaxel)","route":"/terms/taxane/"},{"id":"vrd","kind":"term","name":"VRd and Dara-VRd (myeloma induction regimens)","route":"/terms/vrd/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"}]}}