{"entity":{"id":"dose-dense-chemotherapy","kind":"term","name":"Dose-dense and metronomic chemotherapy","aka":["dose-dense","dose dense","dose-intense","dose intensity","interval-compressed","metronomic","metronomic chemotherapy","low-dose metronomic","dose-dense AC","weekly paclitaxel"],"tldr":"Two opposite ways of rescheduling the same drugs: dose-dense gives standard doses more often (every two weeks instead of three, supported by growth factors) to deny the tumour recovery time; metronomic gives small doses continuously to attack tumour blood vessels with little toxicity.","summary":"Dose-dense adjuvant chemotherapy improved survival in breast cancer (CALGB 9741, EBCTCG meta-analysis) and interval-compressed VDC/IE is standard in Ewing sarcoma; it needs G-CSF support. Metronomic oral chemotherapy (capecitabine, cyclophosphamide, methotrexate, vinorelbine) exploits anti-angiogenic and immune effects, is cheap and well tolerated, and is used in maintenance (CM in triple-negative breast, SYSUCC-001) and low-resource settings such as Tata Memorial's head and neck trials. Both are examples of gaining efficacy from schedule rather than new molecules.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Metronomic_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Metronomic_therapy"}],"tags":[],"related":["chemotherapy-regimen","neutropenia","maintenance-therapy"],"cancers":["tnbc","sarcoma","head-and-neck"],"sections":["chemotherapy"],"technologies":["cytotoxic-chemotherapy","g-csf-growth-factors"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/dose-dense-chemotherapy/","neighbours":{"term":[{"id":"maintenance-therapy","kind":"term","name":"Maintenance therapy","route":"/terms/maintenance-therapy/"},{"id":"neutropenia","kind":"term","name":"Neutropenia","route":"/terms/neutropenia/"},{"id":"chemotherapy-regimen","kind":"term","name":"Regimen and cycles","route":"/terms/chemotherapy-regimen/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"g-csf-growth-factors","kind":"technology","name":"Growth factors: G-CSF and febrile neutropenia prevention","route":"/technologies/g-csf-growth-factors/"}]}}