{"entity":{"id":"docetaxel","kind":"drug","name":"Docetaxel","aka":[],"tldr":"The first chemotherapy to extend life in prostate cancer (2004), now part of triplet therapy at first metastatic diagnosis.","summary":"Docetaxel is a taxane that stabilises microtubules and arrests dividing cells; in prostate cancer it also disrupts androgen receptor nuclear trafficking. It was the first chemotherapy to extend life in metastatic castration-resistant prostate cancer (TAX 327, 2004) and later moved to first metastatic diagnosis: CHAARTED (OS 57.6 versus 44.0 months, HR 0.61) and STAMPEDE showed an overall survival benefit in high-volume hormone-sensitive disease, and PEACE-1 and ARASENS built triplets by adding abiraterone or darolutamide. It is also widely used in breast, lung, gastric and head and neck cancers. Neutropenia, neuropathy and fluid retention limit its use in frail patients, and whether men with low-volume metastatic disease gain anything from it remains contested. For a newcomer, it is the workhorse chemotherapy given every three weeks across many cancers.","status":"approved","asOf":"2026-09-06","wikipedia":"https://en.wikipedia.org/wiki/Docetaxel","links":[{"label":"FDA label (DailyMed)","url":"https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Docetaxel"},{"label":"NICE TA101: docetaxel for the treatment of hormone-refractory metastatic prostate cancer","url":"https://www.nice.org.uk/guidance/ta101"},{"label":"TAX 327 (New England Journal of Medicine 2004)","url":"https://doi.org/10.1056/NEJMoa040720"}],"tags":[],"related":["acupuncture-chemotherapy-neuropathy"],"cancers":["prostate","nsclc","breast-hr-positive","gastric","head-and-neck","prostate-mhspc","prostate-mcrpc","tnbc","tnbc-metastatic","tnbc-early","lung-cancer"],"sections":[],"technologies":["cytotoxic-chemotherapy"],"targets":[],"drugs":[],"companies":["sanofi"],"institutions":[],"pathways":[],"terms":["prostate-crpc-sequencing"],"trials":["chaarted","stampede","peace-1","arasens","nct05089734","nct06340568","nct06382129","nct05348577","nct06520345","nct07518173","nct06699212","nct06356311","nct06928389","nct06989112","nct06300177","nct07213674","nct06976190","nct06952504","nct06118333","nct01933932","nct06925737","nct02486718","nct06074588","nct07291037","nct07196774","nct06881784","nct06891833","nct07287150","nct04140526","nct07306624","nct05676931","nct04895709","nct06463665","nct05904379","nct06943820","nct05431270","nct06568094","nct06445400","nct07590934","nct07246863","nct02861573","nct05126719","nct06228326","nct07070440","nct05020457","nct07102381","nct06841055","nct05910827","nct05592626","nct05054439","nct05427383","nct06908304","nct05296798","nct07415031","nct06057610","nct05999994","nct07419295","nct05094336","nct06783647","nct03671044","nct04025879","nct05867420","nct07518147","nct06857175","nct06863272","nct06745908","nct06545955","nct03505320","nct00781612","nct06947291","nct06682780","nct06780098","nct06644781","nct07225946","nct06353386","nct05173987","nct06016062","nct06632951","nct05631262","nct07669415","nct06012435","nct06123494","nct06296706","nct06741644","nct04634877","nct06663137","tnt","neopact","checkmate-017","checkmate-057","oak"],"people":[],"bottlenecks":[],"keyPapers":["paper-tpextreme-lancet-oncol-2021"],"journals":[],"dependsOn":[],"notes":["In prostate cancer, NICE TA101 recommends docetaxel within its licensed indications for hormone-refractory metastatic disease only if the Karnofsky performance-status score is 60 percent or more, and requires treatment to stop after up to 10 planned cycles, on severe adverse events, or on clinical, laboratory or imaging progression; repeat cycles are not recommended if the disease recurs after a completed course. TAX 327 is the trial behind it: median survival 18.9 months with three-weekly docetaxel and prednisone against 16.5 with mitoxantrone and prednisone, with pain response in 35 against 22 percent."],"brand":"Taxotere (generic)","modality":"Cytotoxic chemotherapy (taxane)","mechanism":"Microtubule stabilisation; also disrupts AR nuclear trafficking.","approvals":[{"region":"US","year":1996,"indication":"Locally advanced or metastatic breast cancer after chemotherapy (Taxotere, NDA 020449)"},{"region":"US","year":2004,"indication":"Metastatic CRPC (with prednisone)"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[{"date":"1996-05-14","type":"accelerated-approval","region":"US","note":"Accelerated approval on a surrogate endpoint, with a confirmatory trial required.","indication":"Locally advanced or metastatic breast carcinoma that progressed during anthracycline-based therapy or relapsed during anthracycline-based adjuvant 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