{"entity":{"id":"denise-aberle","kind":"person","name":"Denise R. Aberle","aka":[],"tldr":"Principal investigator of the National Lung Screening Trial, which first proved CT screening saves lives.","summary":"Denise Aberle was national principal investigator of the ACRIN arm of the National Lung Screening Trial, whose 2011 result of a 20% reduction in lung cancer mortality with low-dose CT led to the first lung screening recommendations and Medicare coverage in the United States. She continues to work on quantitative imaging and AI for nodule assessment.","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/Denise_Aberle","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Aberle%20DR%5BAuthor%5D%20lung%20screening"}],"tags":["screening","lung","radiology"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["ct","radiology-ai-screening"],"targets":[],"drugs":[],"companies":[],"institutions":["ucla-jonsson"],"pathways":[],"terms":[],"trials":["nlst-nelson"],"people":[],"bottlenecks":[],"keyPapers":["paper-nlst-nejm-2011"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Radiology and Bioengineering, UCLA","institutionId":"ucla-jonsson","specialisms":["Thoracic radiology","Lung cancer screening","Imaging trials","Quantitative imaging"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Aberle%20DR%5BAuthor%5D%20lung%20screening"}],"papers":[{"title":"Reduced lung-cancer mortality with low-dose computed tomographic screening (NLST)","journal":"NEJM","year":2011,"doi":"10.1056/NEJMoa1102873"},{"title":"Results of the two incidence screenings in the National Lung Screening Trial","journal":"NEJM","year":2013,"doi":"10.1056/NEJMoa1208962"}]},"route":"/people/denise-aberle/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"radiology-ai-screening","kind":"technology","name":"AI in radiology","route":"/technologies/radiology-ai-screening/"},{"id":"ct","kind":"technology","name":"CT (computed tomography)","route":"/technologies/ct/"}],"institution":[{"id":"ucla-jonsson","kind":"institution","name":"UCLA Jonsson Comprehensive Cancer Center","route":"/institutions/ucla-jonsson/"}],"trial":[{"id":"nlst-nelson","kind":"trial","name":"NLST & NELSON (low-dose CT screening)","route":"/trials/nlst-nelson/"}],"paper":[{"id":"paper-nlst-nejm-2011","kind":"paper","name":"NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers","route":"/key-papers/paper-nlst-nejm-2011/"}]}}