{"entity":{"id":"decentralised-clinical-trials","kind":"technology","name":"Decentralised and hybrid clinical trials","aka":[],"tldr":"Running parts of a trial at home or locally, with telehealth, home nursing, and remote monitoring, so patients far from big centres can take part.","summary":"Accelerated by the pandemic and FDA guidance (2023-24), decentralised elements include telehealth visits, home infusion or blood draws, local imaging and labs, direct-to-patient drug shipping, and wearables. Vendors: Science 37 (acquired by eMed 2024), Medable, THREAD, Lightship, Walgreens/CVS trial services (partly wound down). Oncology adoption lags other areas because of IV drugs and imaging, but hybrid designs (local labs, remote consent) are common.","status":"established","asOf":"2026-09-08","links":[{"label":"Unger: most patients never get the chance to join a cancer trial, and when offered, half say yes (JNCI: Journal of the National Cancer Institute 2019)","url":"https://doi.org/10.1093/jnci/djy221"}],"tags":["supporting"],"related":[],"cancers":[],"sections":["ai-computation","supportive-care"],"technologies":["clinical-trial-software","remote-patient-monitoring"],"targets":[],"drugs":[],"companies":["medable","science-37"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Decentralised trials combine remote consent and data capture, mobile nursing networks, and local investigator sites coordinated through a central protocol.","strengths":["Access and diversity","Retention"],"limitations":["IV regimens and imaging need sites","Data quality and oversight","Vendor consolidation"]},"route":"/technologies/decentralised-clinical-trials/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"supportive-care","kind":"section","name":"Supportive Care & Survivorship","route":"/fronts/supportive-care/"}],"technology":[{"id":"clinical-trial-software","kind":"technology","name":"Clinical trial software (EDC, eCOA, CTMS, RTSM)","route":"/technologies/clinical-trial-software/"},{"id":"remote-patient-monitoring","kind":"technology","name":"Electronic patient-reported outcomes and remote monitoring","route":"/technologies/remote-patient-monitoring/"},{"id":"telemedicine-teleoncology","kind":"technology","name":"Telemedicine, teleoncology, and telepathology","route":"/technologies/telemedicine-teleoncology/"}],"company":[{"id":"medable","kind":"company","name":"Medable","route":"/companies/medable/"},{"id":"science-37","kind":"company","name":"Science 37 (eMed)","route":"/companies/science-37/"}],"paper":[{"id":"paper-unger-trial-participation-barriers-jnci-2019","kind":"paper","name":"Unger: most patients never get the chance to join a cancer trial, and when offered, half say yes","route":"/key-papers/paper-unger-trial-participation-barriers-jnci-2019/"}],"term":[{"id":"accrual","kind":"term","name":"Accrual and enrolment","route":"/terms/accrual/"},{"id":"eu-clinical-trials-regulation","kind":"term","name":"Clinical Trials Regulation (EU) No 536/2014 and CTIS","route":"/terms/eu-clinical-trials-regulation/"},{"id":"ich-gcp","kind":"term","name":"ICH good clinical practice (E6)","route":"/terms/ich-gcp/"}]}}