{"entity":{"id":"debulking","kind":"term","name":"Debulking (cytoreductive surgery)","aka":["cytoreductive surgery","cytoreduction","cytoreductive","primary debulking","interval debulking","interval cytoreduction","secondary cytoreduction","complete cytoreduction","optimal debulking"],"tldr":"Surgery that removes as much tumour as possible when it cannot all be removed cleanly; leaving nothing visible behind is what matters.","summary":"Central to ovarian cancer, where survival tracks the residual disease after surgery: complete cytoreduction (no visible tumour) is the goal. Primary debulking is done first if feasible; otherwise three cycles of carboplatin-paclitaxel are followed by interval debulking (EORTC 55971, CHORUS). Secondary cytoreduction at platinum-sensitive relapse helps selected patients (DESKTOP III) but not unselected ones (GOG-0213). Cytoreductive surgery plus HIPEC is used for peritoneal disease from appendix, colorectal and ovarian cancers, and cytoreductive nephrectomy in kidney cancer.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Debulking","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Debulking"}],"tags":[],"related":["hipec-procedure","peritoneum","neoadjuvant-adjuvant"],"cancers":["ovarian","rcc"],"sections":["surgery"],"technologies":["hipec"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Procedures"},"route":"/terms/debulking/","neighbours":{"term":[{"id":"hipec-procedure","kind":"term","name":"HIPEC (hyperthermic intraperitoneal chemotherapy)","route":"/terms/hipec-procedure/"},{"id":"intraperitoneal-chemotherapy","kind":"term","name":"Intraperitoneal (IP) chemotherapy","route":"/terms/intraperitoneal-chemotherapy/"},{"id":"neoadjuvant-adjuvant","kind":"term","name":"Neoadjuvant / adjuvant / perioperative","route":"/terms/neoadjuvant-adjuvant/"},{"id":"nephrectomy","kind":"term","name":"Nephrectomy","route":"/terms/nephrectomy/"},{"id":"colorectal-palliation-obstruction-pain","kind":"term","name":"Palliation in colorectal cancer: obstruction, stents, stomas and liver capsule pain","route":"/terms/colorectal-palliation-obstruction-pain/"},{"id":"peritoneum","kind":"term","name":"Peritoneum and peritoneal metastases","route":"/terms/peritoneum/"}],"cancer":[{"id":"cup-favourable-subsets","kind":"cancer","name":"Cancer of unknown primary, favourable subsets","route":"/cancers/cup-favourable-subsets/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"low-grade-appendiceal-mucinous-neoplasm","kind":"cancer","name":"Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei","route":"/cancers/low-grade-appendiceal-mucinous-neoplasm/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"technology":[{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"}],"trial":[{"id":"netherlands-hipec","kind":"trial","name":"Netherlands Cancer Institute HIPEC trial","route":"/trials/netherlands-hipec/"},{"id":"prodige-7","kind":"trial","name":"PRODIGE 7","route":"/trials/prodige-7/"}]}}