{"entity":{"id":"deb-schrag","kind":"person","name":"Deborah Schrag","aka":[],"tldr":"Led PATHFINDER, the first prospective study of a multi-cancer blood test in practice, and the PROSPECT rectal cancer trial.","summary":"Deborah Schrag was principal investigator of PATHFINDER, the first prospective study to return Galleri multi-cancer early detection results to participants and their doctors, which showed a cancer signal in about 1% of people and a positive predictive value near 40%, and of PROSPECT, the Alliance trial showing FOLFOX can replace pelvic radiotherapy for many rectal cancers. She chairs medicine at MSKCC and leads pragmatic outcomes research.","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/Deborah_Schrag","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Schrag%20D%5BAuthor%5D%20PATHFINDER%20OR%20PROSPECT"}],"tags":["early-detection","mced","colorectal"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":["mced"],"targets":[],"drugs":["galleri"],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":["pathfinder-2","nhs-galleri"],"people":[],"bottlenecks":[],"keyPapers":["paper-pathfinder-lancet-2023"],"journals":[],"dependsOn":[],"notes":[],"role":"Chair, Department of Medicine, Memorial Sloan Kettering Cancer Center","institutionId":"mskcc","specialisms":["Multi-cancer early detection","Colorectal cancer","Health services research","Pragmatic trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Schrag%20D%5BAuthor%5D%20PATHFINDER%20OR%20PROSPECT"}],"papers":[{"title":"Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study","journal":"Lancet","year":2023,"doi":"10.1016/S0140-6736(23)01700-2"},{"title":"Preoperative treatment of locally advanced rectal cancer (PROSPECT)","journal":"NEJM","year":2023,"doi":"10.1056/NEJMoa2303269"}],"orcid":"0000-0002-4334-5717"},"route":"/people/deb-schrag/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"technology":[{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"}],"drug":[{"id":"galleri","kind":"drug","name":"Galleri","route":"/drugs/galleri/"}],"institution":[{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"trial":[{"id":"nhs-galleri","kind":"trial","name":"NHS-Galleri","route":"/trials/nhs-galleri/"},{"id":"pathfinder-2","kind":"trial","name":"PATHFINDER 2","route":"/trials/pathfinder-2/"}],"paper":[{"id":"paper-pathfinder-lancet-2023","kind":"paper","name":"PATHFINDER: the first prospective test of a multi-cancer blood test in people without symptoms","route":"/key-papers/paper-pathfinder-lancet-2023/"}],"roadmap":[{"id":"ctdna-tests","kind":"roadmap","name":"ctDNA tests roadmap: from a curiosity in plasma to blood tests that decide treatment","route":"/roadmaps/ctdna-tests/"}]}}