{"entity":{"id":"dclk1","kind":"target","name":"DCLK1","aka":["doublecortin like kinase 1","DCAMKL1","DCLK"],"tldr":"DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.","summary":"UniProt describes DCLK1 as a probable kinase of neuronal migration expressed in the adult brain and, at lower levels, in the gut and other organs. In cancer research it is followed as a marker of tuft-like intestinal stem cells implicated in colorectal and pancreatic tumour initiation, and its transcript and protein levels track each other closely in proteogenomic data.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:2700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2700"},{"label":"UniProt O15075","url":"https://www.uniprot.org/uniprotkb/O15075/entry"}],"tags":["cansim-terms"],"related":[],"cancers":["colorectal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["co-amplification","cancer-ai-vocabulary","mrna-protein-concordance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"DCLK1","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2700","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt O15075","url":"https://www.uniprot.org/uniprotkb/O15075/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:2700","ensembl":"ENSG00000133083","uniprot":"O15075","entrez":"9201","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, \"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9205841/","biology":"Probable kinase in a calcium-signalling pathway controlling neuronal migration; in adults expressed in brain and detectable in heart, liver, spleen, prostate, ovary, small intestine and colon (UniProt O15075).","whereFound":["Locus 13q13.3 (HGNC)."],"targetClass":"kinase","prevalence":[]},"route":"/targets/dclk1/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"}]}}