{"entity":{"id":"david-tuveson","kind":"person","name":"David A. Tuveson","aka":[],"tldr":"Built the pancreatic cancer organoid models now used to test drugs against a patient's own tumour.","summary":"David A. Tuveson is Director of the Cold Spring Harbor Laboratory Cancer Center and Roy J. Zuckerberg Professor, specialising in pancreatic ductal adenocarcinoma. He is known for building the first pancreatic ductal organoid models, now used to test drugs against a patient's own tumour, and the mouse models that defined stromal biology in the disease. His selected papers describe organoid models of human and mouse ductal pancreatic cancer and organoid profiling that identifies common responders to chemotherapy. His laboratory drives organoid pharmacotyping trials and functional ex vivo drug testing, and he is a Lustgarten Foundation leader.","asOf":"2026-09-08","links":[{"label":"CSHL profile","url":"https://www.cshl.edu/research/faculty-staff/david-tuveson/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Tuveson%20DA%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["organoids","pdac-organoid-pharmacotyping","functional-drug-testing"],"targets":[],"drugs":[],"companies":[],"institutions":["cold-spring-harbor"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, CSHL Cancer Center; Roy J. Zuckerberg Professor","institutionId":"cold-spring-harbor","specialisms":["Pancreatic cancer","Organoids","Tumour stroma"],"profiles":[{"label":"CSHL profile","url":"https://www.cshl.edu/research/faculty-staff/david-tuveson/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Tuveson%20DA%5BAuthor%5D"}],"papers":[{"title":"Organoid models of human and mouse ductal pancreatic cancer","journal":"Cell","year":2015,"url":"https://doi.org/10.1016/j.cell.2014.12.021","doi":"10.1016/j.cell.2014.12.021"},{"title":"Organoid profiling identifies common responders to chemotherapy in pancreatic cancer","journal":"Cancer Discovery","year":2018,"url":"https://doi.org/10.1158/2159-8290.CD-18-0349","doi":"10.1158/2159-8290.CD-18-0349"}],"orcid":"0000-0002-8017-2712"},"route":"/people/david-tuveson/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"functional-drug-testing","kind":"technology","name":"Functional (ex vivo) drug testing","route":"/technologies/functional-drug-testing/"},{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"},{"id":"pdac-organoid-pharmacotyping","kind":"technology","name":"PDAC organoid pharmacotyping","route":"/technologies/pdac-organoid-pharmacotyping/"}],"institution":[{"id":"cold-spring-harbor","kind":"institution","name":"Cold Spring Harbor Laboratory","route":"/institutions/cold-spring-harbor/"},{"id":"lustgarten-foundation","kind":"institution","name":"Lustgarten Foundation","route":"/institutions/lustgarten-foundation/"},{"id":"stand-up-to-cancer","kind":"institution","name":"Stand Up To Cancer","route":"/institutions/stand-up-to-cancer/"}],"paper":[{"id":"paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019","kind":"paper","name":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","route":"/key-papers/paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019/"},{"id":"paper-ohlund-caf-subtypes-mycaf-icaf-jem-2017","kind":"paper","name":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","route":"/key-papers/paper-ohlund-caf-subtypes-mycaf-icaf-jem-2017/"},{"id":"paper-olive-hedgehog-stroma-gemcitabine-delivery-science-2009","kind":"paper","name":"Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer","route":"/key-papers/paper-olive-hedgehog-stroma-gemcitabine-delivery-science-2009/"},{"id":"paper-aguirre-real-time-genomic-characterisation-pancreatic-cancer-discov-2018","kind":"paper","name":"Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine","route":"/key-papers/paper-aguirre-real-time-genomic-characterisation-pancreatic-cancer-discov-2018/"},{"id":"paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013","kind":"paper","name":"Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer","route":"/key-papers/paper-feig-cxcl12-fap-cafs-t-cell-exclusion-pnas-2013/"},{"id":"paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020","kind":"paper","name":"Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution","route":"/key-papers/paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020/"}]}}