{"entity":{"id":"david-porter","kind":"person","name":"David L. Porter","aka":[],"tldr":"Treated the first adult CLL patients with CAR-T and reported a decade of durable remissions.","summary":"David L. Porter is the Jodi Fisher Horowitz Professor in Leukemia Care Excellence and Director of Cell Therapy and Transplant at the Abramson Cancer Center, University of Pennsylvania. He is known for treating the first adult patients with chronic lymphocytic leukaemia using CAR-T cells, leading the clinical side of Penn's first CTL019 studies. His selected paper reports decade-long leukaemia remissions with persistence of CD4-positive CAR T cells in long-term responders. He now leads cell therapy and stem cell transplant at Penn, spanning CAR-T for leukaemia and allogeneic transplantation.","asOf":"2026-09-08","links":[{"label":"Penn profile","url":"https://www.pennmedicine.org/providers/profile/david-porter"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Porter%20DL%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["cll","all-leukemia"],"sections":[],"technologies":["car-t","allogeneic-hsct"],"targets":["cd19"],"drugs":["tisagenlecleucel"],"companies":[],"institutions":["penn-abramson"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Jodi Fisher Horowitz Professor in Leukemia Care Excellence; Director, Cell Therapy and Transplant","institutionId":"penn-abramson","specialisms":["CAR-T","Chronic lymphocytic leukaemia","Stem cell transplant"],"profiles":[{"label":"Penn profile","url":"https://www.pennmedicine.org/providers/profile/david-porter"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Porter%20DL%5BAuthor%5D"}],"papers":[{"title":"Decade-long leukaemia remissions with persistence of CD4+ CAR T cells","journal":"Nature","year":2022,"url":"https://doi.org/10.1038/s41586-021-04390-6","doi":"10.1038/s41586-021-04390-6"},{"title":"Maude 2014: CD19 CAR-T cells produce complete remission in 27 of 30 children and adults with relapsed ALL","journal":"New England Journal of Medicine","year":2014,"url":"https://doi.org/10.1056/NEJMoa1407222","doi":"10.1056/NEJMoa1407222"}]},"route":"/people/david-porter/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"}],"technology":[{"id":"allogeneic-hsct","kind":"technology","name":"Allogeneic stem cell transplantation","route":"/technologies/allogeneic-hsct/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"}],"drug":[{"id":"tisagenlecleucel","kind":"drug","name":"Tisagenlecleucel","route":"/drugs/tisagenlecleucel/"}],"institution":[{"id":"penn-abramson","kind":"institution","name":"Abramson Cancer Center, University of Pennsylvania","route":"/institutions/penn-abramson/"}],"person":[{"id":"emily-whitehead","kind":"person","name":"Emily Whitehead","route":"/people/emily-whitehead/"}],"paper":[{"id":"paper-maude-ctl019-all-nejm-2014","kind":"paper","name":"Maude 2014: CD19 CAR-T cells produce complete remission in 27 of 30 children and adults with relapsed ALL","route":"/key-papers/paper-maude-ctl019-all-nejm-2014/"}]}}