{"entity":{"id":"david-palma","kind":"person","name":"David A. Palma","aka":[],"tldr":"Led SABR-COMET, the trial that showed treating a few metastases with high-dose radiation can prolong survival.","summary":"David Palma (London, Ontario) was principal investigator of SABR-COMET, the randomised phase 2 trial showing stereotactic ablative radiotherapy to all sites of oligometastatic disease improves overall survival, which launched the oligometastatic treatment paradigm and the SABR-COMET-3 and -10 phase 3 trials. He also studies treatment de-escalation in head and neck cancer and hosts a widely used teaching channel.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Palma%20DA%5BAuthor%5D%20SABR-COMET"}],"tags":["radiotherapy","oligometastatic","sbrt"],"related":[],"cancers":[],"sections":[],"technologies":["sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":["lhsc-verspeeten"],"pathways":[],"terms":["oligometastatic","sbrt-term","radiotherapy","de-escalation"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Radiation Oncologist, London Health Sciences Centre; Professor, Western University","institutionId":"lhsc-verspeeten","specialisms":["Oligometastatic disease","Stereotactic radiotherapy","Pragmatic trial design"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Palma%20DA%5BAuthor%5D%20SABR-COMET"}],"papers":[{"title":"Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET)","journal":"Lancet","year":2019,"doi":"10.1016/S0140-6736(18)32487-5"},{"title":"Stereotactic ablative radiotherapy for the comprehensive treatment of oligometastatic cancers: long-term results of the SABR-COMET phase II randomized trial","journal":"JCO","year":2020,"doi":"10.1200/JCO.20.00818"}],"orcid":"0000-0002-9542-0627"},"route":"/people/david-palma/","neighbours":{"technology":[{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}],"institution":[{"id":"lhsc-verspeeten","kind":"institution","name":"Verspeeten Family Cancer Centre, London Health Sciences Centre","route":"/institutions/lhsc-verspeeten/"}],"term":[{"id":"de-escalation","kind":"term","name":"De-escalation, escalation and response-adapted therapy","route":"/terms/de-escalation/"},{"id":"oligometastatic","kind":"term","name":"Oligometastatic disease","route":"/terms/oligometastatic/"},{"id":"radiotherapy","kind":"term","name":"Radiotherapy","route":"/terms/radiotherapy/"},{"id":"sbrt-term","kind":"term","name":"Stereotactic body radiotherapy (SBRT / SABR)","route":"/terms/sbrt-term/"}]}}