{"entity":{"id":"daniel-spratt","kind":"person","name":"Daniel E. Spratt","aka":[],"tldr":"Radiation oncologist who built AI models from trial slides to decide which prostate cancer patients need hormone therapy.","summary":"Daniel Spratt led the development and validation of the ArteraAI multimodal AI prostate test using digitised pathology and clinical data from NRG/RTOG trials, the first AI biomarker to enter NCCN prostate guidelines. He has led analyses of the Decipher genomic classifier and chairs NRG GU trials of biomarker-guided treatment intensification and de-intensification.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Spratt%20DE%5BAuthor%5D%20prostate%20artificial%20intelligence"}],"tags":["prostate","ai","radiotherapy"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["digital-pathology-ai","imrt-igrt"],"targets":[],"drugs":["artera-ai-prostate"],"companies":[],"institutions":["case-ccc"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nejm-evidence"],"dependsOn":[],"notes":[],"role":"Chair of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University","institutionId":"case-ccc","specialisms":["Prostate radiotherapy","AI biomarkers","Genomic classifiers","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Spratt%20DE%5BAuthor%5D%20prostate%20artificial%20intelligence"}],"papers":[{"title":"Artificial intelligence predictive model for hormone therapy use in prostate cancer","journal":"NEJM Evidence","year":2023},{"title":"Individual patient-level meta-analysis of the performance of the Decipher genomic classifier in high-risk men after prostatectomy to predict development of metastatic disease","journal":"JCO","year":2017,"doi":"10.1200/JCO.2016.70.2811"}],"orcid":"0000-0002-5973-4741"},"route":"/people/daniel-spratt/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"digital-pathology-ai","kind":"technology","name":"Digital pathology & AI","route":"/technologies/digital-pathology-ai/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"drug":[{"id":"artera-ai-prostate","kind":"drug","name":"ArteraAI Prostate","route":"/drugs/artera-ai-prostate/"}],"institution":[{"id":"case-ccc","kind":"institution","name":"Case Comprehensive Cancer Center","route":"/institutions/case-ccc/"}],"journal":[{"id":"nejm-evidence","kind":"journal","name":"NEJM Evidence","route":"/journals/nejm-evidence/"}]}}