{"entity":{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","aka":[],"tldr":"Cytotoxic chemotherapy drugs (platinums, antimetabolites, microtubule agents and topoisomerase inhibitors) kill rapidly dividing cells by damaging DNA or the mitotic spindle. They still cure testicular cancer, lymphoma and leukaemia, and they are the warhead inside antibody-drug conjugates, but a narrow margin between effective and toxic doses is their limitation.","summary":"Classes: alkylators and platinums (cisplatin, carboplatin, cyclophosphamide), antimetabolites (5-FU, capecitabine, gemcitabine, methotrexate), microtubule agents (paclitaxel, docetaxel, eribulin, vinca alkaloids), topoisomerase inhibitors (irinotecan, doxorubicin, etoposide). Progress is in scheduling (dose-dense), biomarker-guided omission, and packaging as ADC payloads.","status":"standard-of-care","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Chemotherapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Chemotherapy"}],"tags":[],"related":["genomic-assay-to-chemo-omission","body-surface-area-dosing","log-kill-hypothesis"],"cancers":[],"sections":["chemotherapy"],"technologies":[],"targets":[],"drugs":["raltitrexed","vindesine","alitretinoin","estramustine","floxuridine","streptozocin","teniposide","altretamine","plicamycin","amsacrine","uracil-mustard","mitobronitol","pipobroman","doxifluridine","plitidepsin"],"companies":["lupin","intas","shasqi","telik","vion-pharmaceuticals"],"institutions":[],"pathways":[],"terms":["efflux-pump"],"trials":["euramos-1","gefitinib-chemo-tmh"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["cancer-chemotherapy-and-pharmacology","gan-to-kagaku-ryoho"],"dependsOn":[],"notes":[],"principle":"DNA damage, antimetabolite incorporation, or mitotic spindle disruption in 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