{"entity":{"id":"cystectomy","kind":"term","name":"Radical cystectomy","aka":["cystectomy","cystectomies"],"tldr":"Removing the bladder (and nearby organs) for bladder cancer that has grown into the muscle wall; urine is then diverted through a stoma or a new bladder made of bowel.","summary":"The standard for muscle-invasive bladder cancer (MIBC), preceded by cisplatin-based neoadjuvant chemotherapy or, since NIAGARA, chemo-immunotherapy. Reconstruction uses an ileal conduit (external bag) or an orthotopic neobladder. It is a major operation with 60% complication rates and a permanent change to daily life, so bladder-sparing trimodality therapy (TURBT plus chemoradiation) and, for patients with complete response to enfortumab vedotin plus pembrolizumab, bladder preservation trials are active alternatives.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Cystectomy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Cystectomy"}],"tags":[],"related":["turbt","stoma","nmibc-vs-mibc","organ-preservation"],"cancers":["urothelial"],"sections":["surgery"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["niagara"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Procedures"},"route":"/terms/cystectomy/","neighbours":{"term":[{"id":"intravesical-therapy","kind":"term","name":"Intravesical therapy (BCG and bladder instillations)","route":"/terms/intravesical-therapy/"},{"id":"nmibc-vs-mibc","kind":"term","name":"Non-muscle-invasive vs muscle-invasive bladder cancer (NMIBC / MIBC)","route":"/terms/nmibc-vs-mibc/"},{"id":"organ-preservation","kind":"term","name":"Organ preservation (watch-and-wait, bladder-sparing, larynx preservation)","route":"/terms/organ-preservation/"},{"id":"stoma","kind":"term","name":"Stoma (colostomy, ileostomy, urostomy)","route":"/terms/stoma/"},{"id":"turbt","kind":"term","name":"Transurethral resection of bladder tumour (TURBT)","route":"/terms/turbt/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"muscle-invasive-bladder-cancer","kind":"cancer","name":"Muscle-invasive and advanced bladder cancer","route":"/cancers/muscle-invasive-bladder-cancer/"},{"id":"non-muscle-invasive-bladder-cancer","kind":"cancer","name":"Non-muscle-invasive bladder cancer","route":"/cancers/non-muscle-invasive-bladder-cancer/"}],"section":[{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"trial":[{"id":"niagara","kind":"trial","name":"NIAGARA","route":"/trials/niagara/"}]}}