{"entity":{"id":"cxbladder","kind":"drug","name":"Cxbladder","aka":[],"tldr":"A urine test that can rule out bladder cancer in people with blood in their urine, so fewer need a camera examination of the bladder.","summary":"Cxbladder (Pacific Edge, New Zealand) is a laboratory-developed urine test used in the work-up of haematuria (Detect and Triage) and in surveillance after treated non-muscle-invasive bladder cancer (Monitor), where its high negative predictive value lets low-risk patients skip some cystoscopies. It is included in US urology guidance for haematuria as an adjunct and has been used in New Zealand's public system and in US Veterans Affairs and Kaiser pathways. US Medicare coverage has been contested through the MolDX programme in 2024-25, which illustrates how reimbursement, more than regulation, decides which tests survive.","status":"established","asOf":"2026-09-10","links":[{"label":"Pacific Edge: Cxbladder","url":"https://www.cxbladder.com"}],"tags":["test"],"related":["urovysion"],"cancers":["urothelial"],"sections":[],"technologies":["cystoscopy-turbt","rna-seq"],"targets":[],"drugs":[],"companies":["pacific-edge"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["What a result means: a negative Cxbladder in someone with low-risk haematuria makes bladder cancer very unlikely; a positive result leads to cystoscopy."],"brand":"Cxbladder Detect / Triage / Monitor","modality":"Urine mRNA biomarker test (bladder cancer detection and surveillance)","mechanism":"RT-qPCR of five mRNA markers (IGFBP5, HOXA13, MDK, CDK1, CXCR2) in voided urine, combined with clinical variables in the Triage version, to rule out urothelial carcinoma.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/cxbladder/","neighbours":{"drug":[{"id":"urovysion","kind":"drug","name":"UroVysion Bladder Cancer Kit","route":"/drugs/urovysion/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"}],"technology":[{"id":"bladder-epicheck","kind":"technology","name":"Bladder EpiCheck urine methylation test","route":"/technologies/bladder-epicheck/"},{"id":"cystoscopy-turbt","kind":"technology","name":"Cystoscopy, blue-light imaging & TURBT","route":"/technologies/cystoscopy-turbt/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"},{"id":"urine-bladder-cancer-tests","kind":"technology","name":"Urine tests for bladder cancer (cytology, FISH, RNA and methylation)","route":"/technologies/urine-bladder-cancer-tests/"}],"company":[{"id":"pacific-edge","kind":"company","name":"Pacific Edge","route":"/companies/pacific-edge/"}],"target":[{"id":"hoxa13","kind":"target","name":"HOXA13","route":"/targets/hoxa13/"}]}}