{"entity":{"id":"crb-701","kind":"drug","name":"CRB-701","aka":[],"tldr":"CRB-701 is an experimental antibody-drug conjugate from Corbus Pharmaceuticals in phase 2 trials, aimed at Nectin-4.","summary":"CRB-701 is an antibody-drug conjugate developed by Corbus Pharmaceuticals. Its target is Nectin-4 (the sponsor names Nectin-4). ClinicalTrials.gov describes the intervention as: Nectin-4 targeted Antibody Drug Conjugate (ADC). It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial. The largest, NCT06265727, plans to enrol 348 participants with primary completion expected 2027-01-16. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.","status":"phase-2","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov: trials of CRB-701","url":"https://clinicaltrials.gov/search?intr=CRB-701"},{"label":"Sponsor page","url":"https://www.corbuspharma.com"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["nectin4"],"drugs":[],"companies":["corbus-pharmaceuticals"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06265727"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor pipeline pages)","editedOn":"2026-09-11"},"modality":"ADC","mechanism":"Antibody-drug conjugate directed at Nectin-4, as stated in the ClinicalTrials.gov intervention record; the detailed mechanism is not stated.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/crb-701/","neighbours":{"target":[{"id":"nectin4","kind":"target","name":"Nectin-4","route":"/targets/nectin4/"}],"company":[{"id":"corbus-pharmaceuticals","kind":"company","name":"Corbus Pharmaceuticals","route":"/companies/corbus-pharmaceuticals/"}],"trial":[{"id":"nct06265727","kind":"trial","name":"A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors","route":"/trials/nct06265727/"}]}}