{"entity":{"id":"cptac","kind":"collection","name":"CPTAC (Clinical Proteomic Tumor Analysis Consortium)","aka":["CPTAC pipelines","Clinical Proteomic Tumor Analysis Consortium"],"tldr":"CPTAC measures the proteins, not just the genes, of thousands of tumours.","summary":"CPTAC, the Clinical Proteomic Tumor Analysis Consortium, holds proteogenomic data, mass spectrometry proteomics and phosphoproteomics, on tumours linked to TCGA, measuring the proteins rather than just the genes of thousands of tumours. This reveals pathway activity and ADC target abundance that DNA and RNA profiling miss. The consortium is run by the NCI and the data are open. On OnCo it is tied to the technology Proteomics and phosphoproteomics, cited by the bottleneck Data silos and the idea Link single-cell and spatial tumour atlases to clinical outcomes, and referenced by the journal record Cancer Cell and the Drug discovery roadmap.","asOf":"2026-09-04","links":[{"label":"CPTAC (Clinical Proteomic Tumor Analysis Consortium)","url":"https://proteomics.cancer.gov"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["proteomics"],"targets":[],"drugs":[],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"url":"https://proteomics.cancer.gov","holds":"Proteogenomic data (mass spectrometry proteomics and phosphoproteomics) on TCGA-linked tumours.","license":"Open","maintainer":"NCI"},"route":"/collections/cptac/","neighbours":{"technology":[{"id":"proteomics","kind":"technology","name":"Proteomics & phosphoproteomics","route":"/technologies/proteomics/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"bottleneck":[{"id":"b-data-silos","kind":"bottleneck","name":"Data silos","route":"/bottlenecks/b-data-silos/"}],"idea":[{"id":"idea-data-atlas-to-outcome-linkage","kind":"idea","name":"Link single-cell and spatial tumour atlases to clinical outcomes","route":"/ideas/idea-data-atlas-to-outcome-linkage/"}],"journal":[{"id":"cancer-cell","kind":"journal","name":"Cancer Cell","route":"/journals/cancer-cell/"}],"roadmap":[{"id":"drug-discovery-roadmap","kind":"roadmap","name":"Drug discovery roadmap: screening in mice → maps of dependency → designing in silico","route":"/roadmaps/drug-discovery-roadmap/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"mass-spec-proteome","kind":"term","name":"Deep mass-spectrometry proteome (CPTAC)","route":"/terms/mass-spec-proteome/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"}]}}