{"entity":{"id":"costas-lyssiotis","kind":"person","name":"Costas A. Lyssiotis","aka":[],"tldr":"Costas Lyssiotis shows how pancreatic tumours feed off their surrounding cells and how to cut the supply.","summary":"Costas A. Lyssiotis is Maisel Research Professor of Oncology at the University of Michigan Rogel Cancer Center, working on cancer metabolism in pancreatic cancer. He is known for showing how pancreatic tumours feed off their surrounding cells, describing the exchange of alanine between pancreatic stellate cells and cancer cells. His selected paper reports that pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. He now studies tumour-stroma metabolic crosstalk and metabolic dependencies that could be exploited with drugs.","asOf":"2026-09-08","links":[{"label":"Michigan profile","url":"https://www.rogelcancercenter.org/costas-lyssiotis-phd"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lyssiotis%20CA%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["michigan-rogel"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Maisel Research Professor of Oncology","institutionId":"michigan-rogel","specialisms":["Cancer metabolism","Pancreatic cancer","Tumour-stroma metabolic crosstalk"],"profiles":[{"label":"Michigan profile","url":"https://www.rogelcancercenter.org/costas-lyssiotis-phd"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Lyssiotis%20CA%5BAuthor%5D"}],"papers":[{"title":"Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion","journal":"Nature","year":2016,"url":"https://doi.org/10.1038/nature19084","doi":"10.1038/nature19084"}],"orcid":"0000-0001-9309-6141"},"route":"/people/costas-lyssiotis/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"institution":[{"id":"michigan-rogel","kind":"institution","name":"University of Michigan Rogel Cancer Center","route":"/institutions/michigan-rogel/"}]}}