{"entity":{"id":"cold-spring-harbor","kind":"institution","name":"Cold Spring Harbor Laboratory","aka":[],"tldr":"Basic-science cancer centre where RAS biology, tumour suppressors, and organoid models were advanced.","summary":"Cold Spring Harbor Laboratory in New York is a basic-science cancer centre with NCI basic designation, where RAS biology, tumour suppressors and organoid models were advanced. Its best-known cancer work is David A. Tuveson's pancreatic cancer organoids, Lowe's p53 and senescence biology and Christopher R. Vakoc's BET and SWI/SNF work, with Bruce W. Stillman, Adrian R. Krainer, Tobias Janowitz and Semir Beyaz also listed. OnCo links it to pancreatic ductal adenocarcinoma, to patient-derived organoids and PDAC organoid pharmacotyping, to the autophagy, cachexia, senescence, MYC and TGF-beta pathways, and to the Lustgarten Foundation. Lab models that fail to predict what happens in patients are the bottleneck its organoid work is meant to relieve, and an open organoid bank for rare cancers is one idea it is linked to. Its pancreatic organoid and p53 programmes are listed below.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Cold_Spring_Harbor_Laboratory","links":[{"label":"Official website","url":"https://www.cshl.edu"}],"tags":[],"related":[],"cancers":["pancreatic"],"sections":[],"technologies":["organoids"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["bruce-stillman","christopher-vakoc","adrian-krainer","tobias-janowitz","semir-beyaz","david-tuveson"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Cold Spring Harbor, NY","country":"US","lat":40.859,"lng":-73.468,"institutionType":"research-institute","website":"https://www.cshl.edu","nci":"basic","programs":["Pancreatic organoids","p53 biology"]},"route":"/institutions/cold-spring-harbor/","neighbours":{"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"technology":[{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"},{"id":"pdac-organoid-pharmacotyping","kind":"technology","name":"PDAC organoid pharmacotyping","route":"/technologies/pdac-organoid-pharmacotyping/"}],"person":[{"id":"adrian-krainer","kind":"person","name":"Adrian R. Krainer","route":"/people/adrian-krainer/"},{"id":"bruce-stillman","kind":"person","name":"Bruce W. Stillman","route":"/people/bruce-stillman/"},{"id":"christopher-vakoc","kind":"person","name":"Christopher R. Vakoc","route":"/people/christopher-vakoc/"},{"id":"david-tuveson","kind":"person","name":"David A. Tuveson","route":"/people/david-tuveson/"},{"id":"marc-lustgarten","kind":"person","name":"Marc Lustgarten","route":"/people/marc-lustgarten/"},{"id":"semir-beyaz","kind":"person","name":"Semir Beyaz","route":"/people/semir-beyaz/"},{"id":"tobias-janowitz","kind":"person","name":"Tobias Janowitz","route":"/people/tobias-janowitz/"}],"paper":[{"id":"paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019","kind":"paper","name":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts","route":"/key-papers/paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019/"},{"id":"paper-ohlund-caf-subtypes-mycaf-icaf-jem-2017","kind":"paper","name":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","route":"/key-papers/paper-ohlund-caf-subtypes-mycaf-icaf-jem-2017/"},{"id":"paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020","kind":"paper","name":"Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution","route":"/key-papers/paper-chan-seng-yue-pancreatic-transcription-phenotypes-nat-genet-2020/"}],"institution":[{"id":"lustgarten-foundation","kind":"institution","name":"Lustgarten Foundation","route":"/institutions/lustgarten-foundation/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-reproducibility","kind":"bottleneck","name":"Preclinical results do not reproduce","route":"/bottlenecks/b-reproducibility/"}],"idea":[{"id":"idea-bio1-rare-cancer-organoid-bank","kind":"idea","name":"An open organoid bank for cancers too rare to have models","route":"/ideas/idea-bio1-rare-cancer-organoid-bank/"},{"id":"idea-cachexia-gdf15-prevention","kind":"idea","name":"Treat cachexia before it starts","route":"/ideas/idea-cachexia-gdf15-prevention/"},{"id":"idea-dtc-colonisation-determinants","kind":"idea","name":"What decides which disseminated cells ever colonise?","route":"/ideas/idea-dtc-colonisation-determinants/"}],"pathway":[{"id":"autophagy","kind":"pathway","name":"Autophagy","route":"/pathways/autophagy/"},{"id":"cachexia-biology","kind":"pathway","name":"Cancer cachexia","route":"/pathways/cachexia-biology/"},{"id":"senescence","kind":"pathway","name":"Cellular senescence","route":"/pathways/senescence/"},{"id":"myc","kind":"pathway","name":"MYC","route":"/pathways/myc/"},{"id":"tgf-beta","kind":"pathway","name":"TGF-β signalling","route":"/pathways/tgf-beta/"},{"id":"metastatic-cascade","kind":"pathway","name":"The metastatic cascade","route":"/pathways/metastatic-cascade/"},{"id":"tumor-dormancy","kind":"pathway","name":"Tumour dormancy","route":"/pathways/tumor-dormancy/"},{"id":"tumor-microenvironment","kind":"pathway","name":"Tumour microenvironment (TME)","route":"/pathways/tumor-microenvironment/"}],"journal":[{"id":"biorxiv","kind":"journal","name":"bioRxiv","route":"/journals/biorxiv/"}]}}