{"entity":{"id":"cnksr2","kind":"target","name":"CNKSR2","aka":["connector enhancer of kinase suppressor of Ras 2","Connector enhancer of kinase suppressor of ras 2","KIAA0902","CNK2","KSR2"],"tldr":"CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May function as an adapter protein or regulator of Ras signalling pathways.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19701","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19701"},{"label":"UniProt Q8WXI2","url":"https://www.uniprot.org/uniprotkb/Q8WXI2/entry"},{"label":"NCBI Gene 22866","url":"https://www.ncbi.nlm.nih.gov/gene/22866"},{"label":"Ensembl ENSG00000149970","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149970"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNKSR2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19701","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19701","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WXI2","url":"https://www.uniprot.org/uniprotkb/Q8WXI2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000149970","url":"https://platform.opentargets.org/target/ENSG00000149970/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:19701","ensembl":"ENSG00000149970","uniprot":"Q8WXI2","entrez":"22866","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus Xp22.12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cnksr2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}