{"entity":{"id":"cl2a","kind":"term","name":"CL2A","aka":[],"tldr":"CL2A is the deliberately fragile linker in Trodelvy: it releases SN-38 in the acidic tumour environment as well as inside cells, feeding the bystander effect.","summary":"CL2A is a pH-sensitive, hydrolysable linker with a short polyethylene glycol spacer. It releases roughly half its payload within a day in plasma, which would be a flaw for a more potent payload but suits moderately potent SN-38 at a very high drug-to-antibody ratio. The result is payload release both inside targeted cells and in the tumour microenvironment.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Sacituzumab_govitecan","links":[{"label":"Humanized anti-Trop-2 IgG-SN-38 (CL2A) conjugate (Cardillo et al., Clin Cancer Res 2011)","url":"https://doi.org/10.1158/1078-0432.CCR-10-2939"}],"tags":[],"related":["sn-38","bystander-effect"],"cancers":[],"sections":[],"technologies":["adc"],"targets":[],"drugs":["sacituzumab-govitecan"],"companies":[],"institutions":[],"pathways":[],"terms":["linker"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-cardillo-clin-cancer-res"],"journals":[],"dependsOn":[],"notes":[],"category":"ADC chemistry"},"route":"/terms/cl2a/","neighbours":{"term":[{"id":"bystander-effect","kind":"term","name":"Bystander effect (ADC)","route":"/terms/bystander-effect/"},{"id":"linker","kind":"term","name":"Linker (ADC)","route":"/terms/linker/"},{"id":"sn-38","kind":"term","name":"SN-38","route":"/terms/sn-38/"}],"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"drug":[{"id":"sacituzumab-govitecan","kind":"drug","name":"Sacituzumab govitecan","route":"/drugs/sacituzumab-govitecan/"}],"paper":[{"id":"paper-cardillo-clin-cancer-res","kind":"paper","name":"Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys","route":"/key-papers/paper-cardillo-clin-cancer-res/"}]}}