{"entity":{"id":"city-of-hope","kind":"institution","name":"City of Hope","aka":[],"tldr":"Los Angeles cancer centre where synthetic insulin and humanised antibodies were developed; a CAR-T manufacturing leader.","summary":"City of Hope in Duarte, near Los Angeles, is an NCI comprehensive cancer centre where synthetic insulin and humanised antibodies were developed, and it is now a leader in CAR-T manufacturing and in CAR-T for brain tumours. Christine E. Brown and Behnam Badie developed IL13Rα2 CAR-T for glioblastoma, the centre runs in-house cell manufacturing and a large transplant programme, and it acquired Cancer Treatment Centers of America, with Robert W. Stone, Steven T. Rosen, Stephen J. Forman, Michael A. Caligiuri, Hope S. Rugo and Alex F. Herrera among the people OnCo lists. OnCo links it to glioma and paediatric neuroblastoma, to the idea of delivering CAR-T straight into the cerebrospinal fluid, and to City of Hope Orange County. The brain as a barrier and sanctuary is the bottleneck its flagship programme confronts. Its CAR-T for glioma and transplant programmes are the ones to read.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://www.cityofhope.org"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["car-t","biology-guided-radiotherapy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["robert-stone","steven-rosen","christine-brown","behnam-badie","virginia-sun","stephen-forman","sumanta-pal","yuman-fong","alex-herrera","hope-rugo","michael-caligiuri","annette-walker"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Duarte, CA","country":"US","lat":34.13,"lng":-117.971,"institutionType":"cancer-center","website":"https://www.cityofhope.org","nci":"comprehensive","programs":["CAR-T for glioma","Transplant"]},"route":"/institutions/city-of-hope/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}],"technology":[{"id":"biology-guided-radiotherapy","kind":"technology","name":"Biology-guided radiotherapy (RefleXion X1, SCINTIX)","route":"/technologies/biology-guided-radiotherapy/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"glioma-car-t","kind":"technology","name":"CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target)","route":"/technologies/glioma-car-t/"}],"person":[{"id":"alex-herrera","kind":"person","name":"Alex F. Herrera","route":"/people/alex-herrera/"},{"id":"annette-walker","kind":"person","name":"Annette Walker","route":"/people/annette-walker/"},{"id":"behnam-badie","kind":"person","name":"Behnam Badie","route":"/people/behnam-badie/"},{"id":"christine-brown","kind":"person","name":"Christine E. Brown","route":"/people/christine-brown/"},{"id":"hope-rugo","kind":"person","name":"Hope S. Rugo","route":"/people/hope-rugo/"},{"id":"michael-caligiuri","kind":"person","name":"Michael A. Caligiuri","route":"/people/michael-caligiuri/"},{"id":"robert-stone","kind":"person","name":"Robert W. Stone","route":"/people/robert-stone/"},{"id":"stephen-forman","kind":"person","name":"Stephen J. Forman","route":"/people/stephen-forman/"},{"id":"steven-rosen","kind":"person","name":"Steven T. Rosen","route":"/people/steven-rosen/"},{"id":"sumanta-pal","kind":"person","name":"Sumanta K. Pal","route":"/people/sumanta-pal/"},{"id":"virginia-sun","kind":"person","name":"Virginia Sun","route":"/people/virginia-sun/"},{"id":"yuman-fong","kind":"person","name":"Yuman Fong","route":"/people/yuman-fong/"}],"institution":[{"id":"city-of-hope-orange-county","kind":"institution","name":"City of Hope Orange County","route":"/institutions/city-of-hope-orange-county/"},{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"parker-institute","kind":"institution","name":"Parker Institute for Cancer Immunotherapy","route":"/institutions/parker-institute/"}],"bottleneck":[{"id":"b-brain-delivery","kind":"bottleneck","name":"The brain: barrier and sanctuary","route":"/bottlenecks/b-brain-delivery/"}],"idea":[{"id":"idea-bio2-intraventricular-car-t","kind":"idea","name":"Deliver CAR-T cells straight into the fluid around the brain","route":"/ideas/idea-bio2-intraventricular-car-t/"}]}}