{"entity":{"id":"cirrhosis","kind":"term","name":"Cirrhosis","aka":["cirrhotic","liver cirrhosis","liver fibrosis","MASLD","MASH","NASH","NAFLD","fatty liver","chronic hepatitis B","hepatitis B","hepatitis C"],"tldr":"Permanent scarring of the liver after years of damage from hepatitis B or C, alcohol or fatty liver disease. It is the soil in which most liver cancers grow, and its severity limits which cancer treatments a patient can withstand.","summary":"Around 80-90% of hepatocellular carcinomas arise in cirrhotic livers, at roughly 2-4% per year, which is why patients with cirrhosis are offered six-monthly ultrasound and AFP surveillance. Hepatitis B vaccination and antiviral therapy, hepatitis C cure with direct-acting antivirals and, prospectively, GLP-1 agonists for metabolic liver disease are the main preventive levers. Cirrhosis also complicates treatment: it causes portal hypertension, low platelets and impaired drug clearance, and is graded by Child-Pugh and ALBI for treatment eligibility.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Cirrhosis","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Cirrhosis"}],"tags":[],"related":["child-pugh","bclc-staging","portal-vein-tumour-thrombus"],"cancers":["hcc"],"sections":["prevention"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Pathology"},"route":"/terms/cirrhosis/","neighbours":{"term":[{"id":"bclc-staging","kind":"term","name":"BCLC staging","route":"/terms/bclc-staging/"},{"id":"child-pugh","kind":"term","name":"Child-Pugh score","route":"/terms/child-pugh/"},{"id":"hepatotoxicity","kind":"term","name":"Hepatotoxicity (liver enzyme elevation)","route":"/terms/hepatotoxicity/"},{"id":"li-rads","kind":"term","name":"LI-RADS (Liver Imaging Reporting and Data System)","route":"/terms/li-rads/"},{"id":"mechanical-theory-of-cancer","kind":"term","name":"Mechanical theory: stiffness, pressure and force as causes","route":"/terms/mechanical-theory-of-cancer/"},{"id":"portal-vein-tumour-thrombus","kind":"term","name":"Portal vein tumour thrombus (macrovascular invasion)","route":"/terms/portal-vein-tumour-thrombus/"}],"cancer":[{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"section":[{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}]}}