{"entity":{"id":"cin-hsil","kind":"term","name":"Cervical precancer (CIN, HSIL/LSIL)","aka":[],"tldr":"Abnormal cervical cells caused by HPV that can turn into cancer over 10-20 years. Screening finds them; a five-minute procedure removes them.","summary":"Cervical intraepithelial neoplasia grades 1-3, now reported as low-grade (LSIL, CIN1) or high-grade (HSIL, CIN2-3) squamous intraepithelial lesions; adenocarcinoma in situ is the glandular equivalent. Most LSIL regresses; ~30% of untreated CIN3 progresses to cancer within 30 years. Treated by LEEP/LLETZ excision, cold-knife cone, cryotherapy, or thermal ablation. HPV16 is the most persistent and carcinogenic type.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Cervical_intraepithelial_neoplasia","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Cervical_intraepithelial_neoplasia"}],"tags":[],"related":[],"cancers":["cervical"],"sections":[],"technologies":["hpv-testing","colposcopy-excision","precancer-ablation"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/cin-hsil/","neighbours":{"cancer":[{"id":"anal-hsil-precursor","kind":"cancer","name":"Anal high-grade squamous intraepithelial lesions (precursor)","route":"/cancers/anal-hsil-precursor/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"vaginal","kind":"cancer","name":"Vaginal cancer","route":"/cancers/vaginal/"},{"id":"vaginal-squamous-cell-carcinoma","kind":"cancer","name":"Vaginal squamous cell carcinoma (HPV-associated)","route":"/cancers/vaginal-squamous-cell-carcinoma/"}],"technology":[{"id":"colposcopy-excision","kind":"technology","name":"Colposcopy and excisional treatment (LEEP/LLETZ, cone)","route":"/technologies/colposcopy-excision/"},{"id":"hpv-testing","kind":"technology","name":"HPV DNA testing and self-sampling","route":"/technologies/hpv-testing/"},{"id":"precancer-ablation","kind":"technology","name":"Thermal ablation and cryotherapy for cervical precancer","route":"/technologies/precancer-ablation/"},{"id":"via-cervical-screening","kind":"technology","name":"Visual inspection with acetic acid (VIA) for cervical screening","route":"/technologies/via-cervical-screening/"}],"person":[{"id":"harald-zur-hausen","kind":"person","name":"Harald zur Hausen","route":"/people/harald-zur-hausen/"},{"id":"jade-goody","kind":"person","name":"Jade Goody","route":"/people/jade-goody/"}],"bottleneck":[{"id":"b-prevention-adoption","kind":"bottleneck","name":"Prevention we already have is not deployed","route":"/bottlenecks/b-prevention-adoption/"}],"pathway":[{"id":"basement-membrane-tissue-barriers","kind":"pathway","name":"Basement membrane & tissue barriers","route":"/pathways/basement-membrane-tissue-barriers/"},{"id":"field-cancerisation","kind":"pathway","name":"Field cancerisation","route":"/pathways/field-cancerisation/"},{"id":"oncogenic-viruses","kind":"pathway","name":"Oncogenic viruses","route":"/pathways/oncogenic-viruses/"}]}}