{"entity":{"id":"chromogranin-a","kind":"term","name":"Chromogranin A","aka":[],"tldr":"Chromogranin A is a protein released by neuroendocrine cells and measured in blood to follow tumour burden; it is unreliable because acid-reducing drugs and kidney disease also raise it.","summary":"Chromogranin A is a protein released by neuroendocrine cells and measured in blood to follow tumour burden in neuroendocrine tumours. Its sensitivity for metastatic disease is variable, and it gives false positives with proton-pump inhibitors, renal impairment and atrophic gastritis, so a single value is hard to interpret. Following the trend over time is more useful than any one measurement. The NETest, a multi-gene blood transcript assay, has been proposed as a replacement. Readers meet the term on the neuroendocrine tumours page, and it matters because acid-reducing drugs and kidney disease can raise it without any change in the cancer.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Chromogranin_A","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Chromogranin_A"}],"tags":[],"related":[],"cancers":["neuroendocrine"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Biomarkers"},"route":"/terms/chromogranin-a/","neighbours":{"cancer":[{"id":"grade-3-net","kind":"cancer","name":"Grade 3 well-differentiated neuroendocrine tumour","route":"/cancers/grade-3-net/"},{"id":"lung-net","kind":"cancer","name":"Lung neuroendocrine tumours (typical and atypical carcinoid)","route":"/cancers/lung-net/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"pancreatic-net","kind":"cancer","name":"Pancreatic neuroendocrine tumours","route":"/cancers/pancreatic-net/"},{"id":"small-intestinal-net","kind":"cancer","name":"Small intestinal neuroendocrine tumours","route":"/cancers/small-intestinal-net/"}],"term":[{"id":"urinary-catecholamines","kind":"term","name":"Urinary catecholamine metabolites (VMA and HVA)","route":"/terms/urinary-catecholamines/"}],"technology":[{"id":"serum-tumour-markers","kind":"technology","name":"Serum tumour markers: proper use and misuse","route":"/technologies/serum-tumour-markers/"}]}}