{"entity":{"id":"christopher-booth","kind":"person","name":"Christopher M. Booth","aka":[],"tldr":"Oncologist who co-led CHALLENGE and founded Common Sense Oncology to refocus trials on outcomes that matter to patients.","summary":"Christopher Booth (Queen's University, Canada) was co-principal investigator of the CHALLENGE trial showing exercise improves survival after colon cancer, and founded Common Sense Oncology, an international movement arguing that trials should measure overall survival and quality of life, avoid weak surrogate endpoints and address affordability. His health services research examines the real-world value of new cancer drugs.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Booth%20CM%5BAuthor%5D%20oncology"}],"tags":["evidence","policy","exercise"],"related":[],"cancers":["colorectal"],"sections":[],"technologies":["exercise-oncology"],"targets":[],"drugs":[],"companies":[],"institutions":["queens-university-kingston"],"pathways":[],"terms":[],"trials":["challenge"],"people":[],"bottlenecks":[],"keyPapers":["paper-challenge-exercise-nejm-2025","paper-prasad-surrogate-endpoints-jama-im-2015"],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Oncology and Public Health Sciences, Queen's University; Medical Oncologist, Kingston Health Sciences Centre","institutionId":"queens-university-kingston","specialisms":["Cancer policy and evidence","Common Sense Oncology","Health services research","Exercise oncology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Booth%20CM%5BAuthor%5D%20oncology"}],"papers":[{"title":"Structured exercise after adjuvant chemotherapy for colon cancer (CHALLENGE)","journal":"NEJM","year":2025},{"title":"Common Sense Oncology: outcomes that matter","journal":"Lancet Oncology","year":2023,"doi":"10.1016/S1470-2045(23)00319-4"},{"title":"CHALLENGE: a structured exercise programme after chemotherapy improves survival in colon cancer","journal":"New England Journal of Medicine","year":2025,"url":"https://doi.org/10.1056/NEJMoa2502760","doi":"10.1056/NEJMoa2502760"},{"title":"Prasad: most surrogate endpoints in cancer trials correlate poorly with survival","journal":"JAMA Internal Medicine","year":2015,"url":"https://doi.org/10.1001/jamainternmed.2015.2829","doi":"10.1001/jamainternmed.2015.2829"}],"orcid":"0000-0002-1505-0575"},"route":"/people/christopher-booth/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}],"technology":[{"id":"exercise-oncology","kind":"technology","name":"Exercise & lifestyle oncology","route":"/technologies/exercise-oncology/"}],"institution":[{"id":"queens-university-kingston","kind":"institution","name":"Queen's University / Kingston Health Sciences Centre","route":"/institutions/queens-university-kingston/"}],"trial":[{"id":"challenge","kind":"trial","name":"CHALLENGE (CCTG CO.21)","route":"/trials/challenge/"}],"paper":[{"id":"paper-challenge-exercise-nejm-2025","kind":"paper","name":"CHALLENGE: a structured exercise programme after chemotherapy improves survival in colon cancer","route":"/key-papers/paper-challenge-exercise-nejm-2025/"},{"id":"paper-prasad-surrogate-endpoints-jama-im-2015","kind":"paper","name":"Prasad: most surrogate endpoints in cancer trials correlate poorly with survival","route":"/key-papers/paper-prasad-surrogate-endpoints-jama-im-2015/"}]}}