{"entity":{"id":"christine-brown","kind":"person","name":"Christine E. Brown","aka":[],"tldr":"Engineered the IL13Rα2 CAR-T cells that produced a complete response in glioblastoma when infused into the brain.","summary":"Christine Brown is Deputy Director of the T Cell Therapeutics Research Laboratories at City of Hope. An immunologist leading CAR-T development for brain tumours, she engineered the IL13Rα2 CAR-T cells that produced a complete response in glioblastoma when infused into the brain. Her papers include the 2016 New England Journal of Medicine case of regression of glioblastoma after intraventricular CAR T-cell therapy and a Nature Medicine phase 1 trial of locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma. Her work established locoregional delivery and continues on armoured and next-generation CAR designs for glioma and glioblastoma.","asOf":"2026-09-08","links":[{"label":"City of Hope research faculty","url":"https://www.cityofhope.org/research/find-a-researcher"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brown%20CE%5BAuthor%5D"},{"label":"Google Scholar","url":"https://scholar.google.com/scholar?q=Christine%20E.%20Brown"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":[],"technologies":["car-t","armored-car"],"targets":[],"drugs":[],"companies":[],"institutions":["city-of-hope"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Deputy Director, T Cell Therapeutics Research Laboratories, City of Hope","institutionId":"city-of-hope","specialisms":["CAR-T cell therapy","Glioblastoma","Regional delivery"],"profiles":[{"label":"City of Hope research faculty","url":"https://www.cityofhope.org/research/find-a-researcher"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brown%20CE%5BAuthor%5D"},{"label":"Google Scholar","url":"https://scholar.google.com/scholar?q=Christine%20E.%20Brown"}],"papers":[{"title":"Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy","journal":"New England Journal of Medicine","year":2016,"url":"https://doi.org/10.1056/NEJMoa1610497","doi":"10.1056/NEJMoa1610497"},{"title":"Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial","journal":"Nature Medicine","year":2024,"url":"https://doi.org/10.1038/s41591-024-02875-1","doi":"10.1038/s41591-024-02875-1"}],"orcid":"0000-0003-4915-8207"},"route":"/people/christine-brown/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"technology":[{"id":"armored-car","kind":"technology","name":"Armoured, logic-gated & next-gen CARs","route":"/technologies/armored-car/"},{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"}],"institution":[{"id":"city-of-hope","kind":"institution","name":"City of Hope","route":"/institutions/city-of-hope/"}]}}