{"entity":{"id":"chipscreen","kind":"company","name":"Chipscreen Biosciences","aka":["微芯生物"],"tldr":"Chipscreen discovered chidamide (tucidinostat), the first original epigenetic cancer drug from China, approved in 2014 and later in Japan.","summary":"Chidamide (Epidaza) approved 2014 for T-cell lymphoma and 2019 for breast cancer; licensed to HUYA Bioscience (HBI-8000) with Japanese approval 2021 and to Meiji Seika; chiglitazar for diabetes. Founded by Xianping Lu, a returnee from US biotech, before China's regulatory reforms made originator research routine.","asOf":"2026-09-10","links":[{"label":"Official website","url":"https://www.chipscreen.com/en/"}],"tags":["china"],"related":[],"cancers":[],"sections":["epigenetics"],"technologies":[],"targets":[],"drugs":["tucidinostat","chiauranib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct06497985","nct06947967"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Shenzhen","country":"CN","companyType":"biotech","website":"https://www.chipscreen.com/en/","ticker":"688321.SS","founded":2001,"investors":[],"funding":[]},"route":"/companies/chipscreen/","neighbours":{"section":[{"id":"epigenetics","kind":"section","name":"Epigenetic & Transcriptional Therapy","route":"/fronts/epigenetics/"}],"drug":[{"id":"chiauranib","kind":"drug","name":"Chiauranib","route":"/drugs/chiauranib/"},{"id":"tucidinostat","kind":"drug","name":"Tucidinostat (chidamide)","route":"/drugs/tucidinostat/"}],"trial":[{"id":"nct06497985","kind":"trial","name":"A Study of Tucidinostat in Combination With Sintilimab and Bevacizumab in MSS/pMMR Colorectal Cancer Patients","route":"/trials/nct06497985/"},{"id":"nct04921527","kind":"trial","name":"Chiauranib Plus Weekly Paclitaxel in Patients with Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer","route":"/trials/nct04921527/"},{"id":"nct06947967","kind":"trial","name":"Tucidinostat in Combination With CHOP in Newly Diagnosed Peripheral T-Cell Lymphoma With Follicular Helper of T Cell Phenotype","route":"/trials/nct06947967/"}],"roadmap":[{"id":"epigenetics-roadmap","kind":"roadmap","name":"Epigenetic therapy roadmap: loosening silenced genes → mutation-specific enzymes → editing the epigenome","route":"/roadmaps/epigenetics-roadmap/"}],"company":[{"id":"huyabio","kind":"company","name":"HUYABIO International","route":"/companies/huyabio/"}]}}