{"entity":{"id":"ching-hon-pui","kind":"person","name":"Ching-Hon Pui","aka":[],"tldr":"Led the St. Jude Total Therapy studies that cure over 90% of children with leukaemia without cranial radiation.","summary":"Ching-Hon Pui has led the St. Jude Total Therapy studies for three decades, showing in Total XV that cranial irradiation can be omitted for all children with acute lymphoblastic leukaemia when MRD-guided intensification is used, and pushing five-year survival above 90%. He has worked to bring these protocols to China and other middle-income countries and has authored the definitive reviews of childhood ALL.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pui%20CH%5BAuthor%5D%20acute%20lymphoblastic%20leukemia"}],"tags":["paediatric","all","st-jude"],"related":[],"cancers":["all-leukemia"],"sections":[],"technologies":["mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":["st-jude"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chair, Department of Oncology, St. Jude Children's Research Hospital","institutionId":"st-jude","specialisms":["Paediatric acute lymphoblastic leukaemia","Risk-adapted therapy","Pharmacogenomics","Global paediatric oncology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pui%20CH%5BAuthor%5D%20acute%20lymphoblastic%20leukemia"}],"papers":[{"title":"Treating childhood acute lymphoblastic leukemia without cranial irradiation (Total Therapy XV)","journal":"NEJM","year":2009,"doi":"10.1056/NEJMoa0900386"},{"title":"Childhood acute lymphoblastic leukemia: progress through collaboration","journal":"JCO","year":2015,"doi":"10.1200/JCO.2014.59.1636"}],"orcid":"0000-0003-0303-5658"},"route":"/people/ching-hon-pui/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"}],"institution":[{"id":"st-jude","kind":"institution","name":"St. Jude Children's Research Hospital","route":"/institutions/st-jude/"}]}}