{"entity":{"id":"childrens-oncology-group","kind":"company","name":"Children's Oncology Group (COG)","aka":["Children's Oncology Group","COG"],"tldr":"The Children's Oncology Group is the world's largest paediatric cancer trials organisation; most children with cancer in North America are treated on or according to a COG protocol.","summary":"The Children's Oncology Group, based in Monrovia, California, is the world's largest paediatric cancer trials organisation, formed in 2000 from four paediatric groups with more than two hundred member hospitals; most children with cancer in North America are treated on or according to a COG protocol. Its trials define risk-adapted therapy: AALL1731 added blinatumomab to chemotherapy for standard-risk B-cell ALL, ANBL0032 established anti-GD2 immunotherapy in neuroblastoma, and AAML0531, ACNS0331 and AHOD2131 cover leukaemia, brain tumours and Hodgkin lymphoma. OnCo connects it to the RACE for Children Act and to bottlenecks on paediatric cancers without markets and neglected late effects. Whether every treated child can be followed for decades through registry linkage is the open idea. Its programmes are listed in the notes.","asOf":"2026-09-06","links":[{"label":"Official website","url":"https://childrensoncologygroup.org"}],"tags":["cooperative-group"],"related":["blinatumomab"],"cancers":["all-leukemia","neuroblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["nci","uw-carbone","cche-57357"],"pathways":[],"terms":[],"trials":[],"people":["douglas-hawkins","alice-yu","julie-park","rachel-rau","susan-cohn"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Paediatric ALL (AALL trials)","Neuroblastoma (ANBL trials)","Survivorship"],"provenance":{"editedBy":"OnCo cooperative groups migration (row 251: institution consortium records moved to cooperative-group companies)","editedOn":"2026-09-25"},"hq":"Monrovia, CA","country":"US","companyType":"cooperative-group","website":"https://childrensoncologygroup.org","founded":2000,"investors":[],"funding":[]},"route":"/companies/childrens-oncology-group/","neighbours":{"drug":[{"id":"blinatumomab","kind":"drug","name":"Blinatumomab","route":"/drugs/blinatumomab/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"aml-paediatric","kind":"cancer","name":"Acute myeloid leukaemia in children","route":"/cancers/aml-paediatric/"},{"id":"aya-cancers","kind":"cancer","name":"Adolescent and young adult cancers (ages 15 to 39)","route":"/cancers/aya-cancers/"},{"id":"advanced-stage-classical-hodgkin-lymphoma","kind":"cancer","name":"Advanced-stage classical Hodgkin lymphoma (stage III to IV)","route":"/cancers/advanced-stage-classical-hodgkin-lymphoma/"},{"id":"atrt","kind":"cancer","name":"Atypical teratoid/rhabdoid tumour 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